Nucleic acid-induced aggregation of metal nanoparticles and uses thereof in methods for detecting nucleic acids

Ramon Alvarez-Puebla (Inventor), Luca Guerrini (Inventor), Juan Sagalés Mañas (Inventor), Duncan Graham (Inventor)

Research output: Patent

Abstract

The invention relates to an aggregate comprising metallic nanoparticles and nucleic acid molecules wherein each metallic nanoparticle is coated with a polycation. The invention also relates to the a method for obtaining the aggregate of the invention and to the use of said aggregate in methods for detecting the presence of a nucleic acid in a sample, in methods for detecting the presence of a given nucleotide at a predetermined position in a target nucleic acid, in methods for detecting the presence of a modified nucleotide at a predetermined position in a target nucleic acid, methods for detecting the presence of a conjugate between a double stranded nucleic acid and a chemical in a sample comprising double stranded nucleic acid molecules, in methods for determining the content of modified nucleotides in a target nucleic acid and in method for determining the content of modified nucleotides in a target nucleic acid.
Original languageEnglish
Priority date23/10/14
Publication statusPublished - 27 Apr 2016

Keywords

  • spectroscopy
  • nucleic acid
  • SERS
  • metallic nanoparticle

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