Nucleic acid and nucleotide-mediated synthesis of inorganic nanoparticles

Lorenzo Berti, Glenn Burley

Research output: Contribution to journalArticle

224 Citations (Scopus)


Since the advent of practical methods for achieving DNA metallization, the use of nucleic acids as templates for the synthesis of inorganic nanoparticles (NPs) has become an active area of study. It is now widely recognized that nucleic acids have the ability to control the growth and morphology of inorganic NPs. These biopolymers are particularly appealing as templating agents as their ease of synthesis in conjunction with the possibility of screening nucleotide composition, sequence and length, provides the means to modulate the physico-chemical properties of the resulting NPs. Several synthetic procedures leading to NPs with interesting photophysical properties as well as studies aimed at rationalizing the mechanism of nucleic acid-templated NP synthesis are now being reported. This
progress article will outline the current understanding of the nucleic acid-templated process and provides an up to date reference in this nascent field.
Original languageEnglish
Pages (from-to)81-87
Number of pages7
JournalNature Nanotechnology
Issue number2
Publication statusPublished - Feb 2008


  • nucleic acids
  • inorganic nanoparticles
  • biopolymers
  • nucleotide composition

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