Nuclear magnetic resonance probing of binding interactions used by minor groove binding, DNA-directed ligands: assignment of the binding site of Hoechst 33258 on the self-complementary oligonucleotide, d(CGCGAATTCGCG)

John Parkinson, Jill Barber, Kenneth T. Douglas, John Rosamond, Derek Sharples

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

The binding of Hoechst 33258 to the minor groove of the duplex formed by the self-complementary oligonucleotide d(CGCGAATTCGCG) has been shown by means of high-field 1H nuclear magnetic resonance spectroscopy to be across the central AATT region of the duplex.
Original languageEnglish
Pages (from-to)1023-1025
Number of pages3
JournalJournal of the Chemical Society, Chemical Communications
Issue number15
DOIs
Publication statusPublished - 1 Jan 1989

Keywords

  • magnetic resonance spectroscopy
  • duplex
  • DNA binding ligands

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