Novel controlled release polymer-lipid formulations processed by hot melt extrusion

Mohammed Maniruzzaman, Muhammad T. Islam, Sheelagh Halsey, Devyani Amin, Dennis Douroumis

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The aim of the study was to investigate the effect of novel polymer/lipid formulations on the dissolution rates of the water insoluble indomethacin (INM), co-processed by hot melt extrusion (HME). Formulations consisted of the hydrophilic hydroxypropyl methyl cellulose polymer (HPMCAS) and stearoyl macrogol-32 glycerides—Gelucire 50/13 (GLC) were processed with a twin screw extruder to produce solid dispersions. The extrudates characterized by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC) and hot stage microscopy (HSM) indicated the presence of amorphous INM within the polymer/lipid matrices. In-line monitoring via near-infrared (NIR) spectroscopy revealed significant peak shifts indicating possible interactions and H-bonding formation between the drug and the polymer/lipid carriers. Furthermore, in vitro dissolution studies showed a synergistic effect of the polymer/lipid carrier with 2-h lag time in acidic media followed by enhanced INM dissolution rates at pH > 5.5.
Original languageEnglish
Pages (from-to)191-199
Number of pages9
JournalAAPS PharmSciTech
Volume17
Issue number1
Early online date21 Dec 2015
DOIs
Publication statusPublished - 29 Feb 2016

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Polymers
Lipids
Indomethacin
hydroxypropylmethylcellulose acetate succinate
Powder Diffraction
Near-Infrared Spectroscopy
Differential Scanning Calorimetry
X-Ray Diffraction
Microscopy
Water
Pharmaceutical Preparations

Keywords

  • controlled release
  • hot melt extrusion
  • in-line NIR
  • solid dispersions
  • polymer/lipid formulations
  • water insoluble indomethacin

Cite this

Maniruzzaman, M., Islam, M. T., Halsey, S., Amin, D., & Douroumis, D. (2016). Novel controlled release polymer-lipid formulations processed by hot melt extrusion. AAPS PharmSciTech, 17(1), 191-199. https://doi.org/10.1208/s12249-015-0470-2
Maniruzzaman, Mohammed ; Islam, Muhammad T. ; Halsey, Sheelagh ; Amin, Devyani ; Douroumis, Dennis. / Novel controlled release polymer-lipid formulations processed by hot melt extrusion. In: AAPS PharmSciTech. 2016 ; Vol. 17, No. 1. pp. 191-199.
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Maniruzzaman, M, Islam, MT, Halsey, S, Amin, D & Douroumis, D 2016, 'Novel controlled release polymer-lipid formulations processed by hot melt extrusion', AAPS PharmSciTech, vol. 17, no. 1, pp. 191-199. https://doi.org/10.1208/s12249-015-0470-2

Novel controlled release polymer-lipid formulations processed by hot melt extrusion. / Maniruzzaman, Mohammed; Islam, Muhammad T.; Halsey, Sheelagh; Amin, Devyani; Douroumis, Dennis.

In: AAPS PharmSciTech, Vol. 17, No. 1, 29.02.2016, p. 191-199.

Research output: Contribution to journalArticle

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AU - Maniruzzaman, Mohammed

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