Novel adducts of the anticancer drug oxaliplatin with glutathione and redox reactions with glutathione disulfide.

Sarah Fakih, Vivienne P. Munk, Michelle A. Shipman, Piedad del Socorro Murdoch, John Parkinson, Peter J. Sadler

Research output: Contribution to journalArticlepeer-review

60 Citations (Scopus)

Abstract

Reactions of [Pt(rac-1,2-DACH)Cl2], [Pt(1R,2R-DACH)Cl2] and the anticancer drug oxaliplatin with the tripeptide glutathione and glutathione disulfide have been studied by HPLC, ESI-MS and NMR methods. The same two major products are formed in each reaction: a thiolate-bridged dimer and a novel thiolate-bridged dinuclear macrochelate containing a nine-membered chelate ring. Redox reactions of PtII anticancer drugs with biological disulfides are of potential importance to their mechanism of action.
Original languageEnglish
Pages (from-to)1206-1214
Number of pages9
JournalEuropean Journal of Inorganic Chemistry
Volume2003
Issue number6
DOIs
Publication statusPublished - 1 Mar 2003

Keywords

  • anti-cancer drugs
  • redox reactions

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