Norlanostane triterpenoidal saponins from the marine sponge melophlussarassinorum

Hao-Fu Dai, Ru Angelie Edrada, Rainer Ebel, Manfred Nimtz, Victor Wray, Peter Proksch, Ruangelie Edrada-Ebel

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Along with five known 30-norlanostane-type saponins, sarasinosides A(1) (5A), A3 (6A), I1 (7), I2 (8), and H2 (9), four new triterpenoidal saponin congeners, sarasinosides J (1), K (2), L (3), and M (4), were isolated from the Indonesian sponge Melophlus sarassinorum. Sarasinosides J (1) and K (2) are the 24,25-hydrogenated congeners of the previously described sarasinosides A1 and H2, respectively. The carbon skeleton of sarasinoside M (4) possesses a rearranged 8alpha,9alpha-epoxy-8,9-seconorlanosta-8(14),9(11),24-triene system, which is novel and unprecedented in nature. The structures of the new compounds were confirmed by spectral analyses, chemical derivatization, and GC analyses. Compounds 1 and 5A exhibited antimicrobial activity toward Bacillus subtilis and Saccharomyces cerevisiae.

LanguageEnglish
Pages1231-1237
Number of pages7
JournalJournal of Natural Products
Volume68
Issue number8
DOIs
Publication statusPublished - Aug 2005

Fingerprint

Saponins
Porifera
Bacilli
Bacillus subtilis
Skeleton
Yeast
Saccharomyces cerevisiae
Carbon
sarasinoside A1

Keywords

  • anti-bacterial agents
  • antifungal agents
  • bacillus subtilis
  • chromatography
  • glycosides
  • lanosterol
  • microbial sensitivity tests
  • molecular structure
  • nuclear magnetic resonance
  • porifera
  • saccharomyces cerevisiae
  • stereoisomerism
  • triterpenes

Cite this

Dai, Hao-Fu ; Edrada, Ru Angelie ; Ebel, Rainer ; Nimtz, Manfred ; Wray, Victor ; Proksch, Peter ; Edrada-Ebel, Ruangelie. / Norlanostane triterpenoidal saponins from the marine sponge melophlussarassinorum. In: Journal of Natural Products. 2005 ; Vol. 68, No. 8. pp. 1231-1237.
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Norlanostane triterpenoidal saponins from the marine sponge melophlussarassinorum. / Dai, Hao-Fu; Edrada, Ru Angelie; Ebel, Rainer; Nimtz, Manfred; Wray, Victor; Proksch, Peter; Edrada-Ebel, Ruangelie.

In: Journal of Natural Products, Vol. 68, No. 8, 08.2005, p. 1231-1237.

Research output: Contribution to journalArticle

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AU - Edrada, Ru Angelie

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AU - Wray, Victor

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