Non-neutral processes drive the nucleotide composition of non-coding sequences in Drosophila

Penelope R Haddrill, Brian Charlesworth

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


The nature of the forces affecting base composition is a key question in genome evolution. There is uncertainty as to whether differences in the GC contents of non-coding sequences reflect differences in mutational bias, or in the intensity of selection or biased gene conversion. We have used a polymorphism dataset for non-coding sequences on the X chromosome of Drosophila simulans to examine this question. The proportion of GC-->AT versus AT-->GC polymorphic mutations in a locus is correlated with its GC content. This implies the action of forces that favour GC over AT base pairs, which are apparently strongest in GC-rich sequences.

Original languageEnglish
Pages (from-to)438-441
Number of pages4
JournalBiology Letters
Issue number4
Publication statusPublished - 23 Aug 2008


  • animals
  • base composition
  • DNA, intergenic
  • drosophila
  • GC rich sequence
  • genetic speciation
  • mutation
  • phylogeny
  • polymorphism, genetic
  • sequence analysis, DNA
  • X chromosome

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