Non-neutral processes drive the nucleotide composition of non-coding sequences in Drosophila

Penelope R Haddrill, Brian Charlesworth

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The nature of the forces affecting base composition is a key question in genome evolution. There is uncertainty as to whether differences in the GC contents of non-coding sequences reflect differences in mutational bias, or in the intensity of selection or biased gene conversion. We have used a polymorphism dataset for non-coding sequences on the X chromosome of Drosophila simulans to examine this question. The proportion of GC-->AT versus AT-->GC polymorphic mutations in a locus is correlated with its GC content. This implies the action of forces that favour GC over AT base pairs, which are apparently strongest in GC-rich sequences.

LanguageEnglish
Pages438-441
Number of pages4
JournalBiology Letters
Volume4
Issue number4
DOIs
Publication statusPublished - 23 Aug 2008

Fingerprint

GC Rich Sequence
Gene Conversion
Base Composition
Chromosomes
Polymorphism
Drosophila
Nucleotides
Genes
nucleotides
Drosophila simulans
gene conversion
selection intensity
X chromosome
Chemical analysis
uncertainty
genetic polymorphism
X Chromosome
mutation
Base Pairing
loci

Keywords

  • animals
  • base composition
  • DNA, intergenic
  • drosophila
  • GC rich sequence
  • genetic speciation
  • mutation
  • phylogeny
  • polymorphism, genetic
  • sequence analysis, DNA
  • X chromosome

Cite this

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Non-neutral processes drive the nucleotide composition of non-coding sequences in Drosophila. / Haddrill, Penelope R; Charlesworth, Brian.

In: Biology Letters, Vol. 4, No. 4, 23.08.2008, p. 438-441.

Research output: Contribution to journalArticle

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