Non-invasive optical interrogation of the ocular anterior chamber

Research output: Contribution to journalConference Contribution

5 Citations (Scopus)

Abstract

Ophthalmic drug research and ocular diagnostics is hampered by an inability to perform continuous sampling of the aqueous humor contained within the anterior chamber by paracentesis is technically problematic and is associated with the use of local or general anesthesia. Moreover, sampling by direct injection exposes the eye to the risk of infection. We report results obtained from an optical instrumentation technique which is concerned with the direct and non-invasive measurements of optical scattering, absorbance and fluorescence produced in the aqueous humor by various compounds, thus avoiding the need for direct sampling. Light scatter in the anterior chamber arises from particulate matter, such as cell debris and chemical precipitates following eye surgery. Absorbance is caused by the presence of materials such as haemoglobin, or results from the penetration of drugs such as hydroxyquinolines applied to the cornea. Fluorescence can be used to provide a sensitive measurements of fluoroquinolines in the anterior chamber.
LanguageEnglish
Pages114-117
Number of pages4
JournalProceedings of SPIE
Volume3483
DOIs
Publication statusPublished - 18 Jun 1998
EventProc. SPIE Vol. 3483: European Workshop on Optical Fibre Sensors - Peebles, United Kingdom
Duration: 8 Jul 199810 Jul 1998

Fingerprint

interrogation
chambers
sampling
Sampling
Fluorescence
Drugs
drugs
Hydroxyquinolines
Cornea
anesthesia
Particulate Matter
General Anesthesia
fluorescence
Hemoglobin
cornea
Direct injection
hemoglobin
infectious diseases
Scatter
Instrumentation

Keywords

  • non-invasive
  • noninvasive
  • optical interrogation
  • ocular anterior chamber
  • scattering
  • surgery
  • absorbance
  • chemical compounds
  • chemicals
  • cornea
  • diagnostics
  • eye
  • luminescence
  • ophthalmology

Cite this

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title = "Non-invasive optical interrogation of the ocular anterior chamber",
abstract = "Ophthalmic drug research and ocular diagnostics is hampered by an inability to perform continuous sampling of the aqueous humor contained within the anterior chamber by paracentesis is technically problematic and is associated with the use of local or general anesthesia. Moreover, sampling by direct injection exposes the eye to the risk of infection. We report results obtained from an optical instrumentation technique which is concerned with the direct and non-invasive measurements of optical scattering, absorbance and fluorescence produced in the aqueous humor by various compounds, thus avoiding the need for direct sampling. Light scatter in the anterior chamber arises from particulate matter, such as cell debris and chemical precipitates following eye surgery. Absorbance is caused by the presence of materials such as haemoglobin, or results from the penetration of drugs such as hydroxyquinolines applied to the cornea. Fluorescence can be used to provide a sensitive measurements of fluoroquinolines in the anterior chamber.",
keywords = "non-invasive, noninvasive, optical interrogation, ocular anterior chamber, scattering, surgery, absorbance, chemical compounds, chemicals, cornea, diagnostics, eye , luminescence, ophthalmology",
author = "Robert Blue and Deepak Uttamchandani and Clive Wilson",
year = "1998",
month = "6",
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doi = "10.1117/12.309653",
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}

Non-invasive optical interrogation of the ocular anterior chamber. / Blue, Robert; Uttamchandani, Deepak; Wilson, Clive.

In: Proceedings of SPIE, Vol. 3483, 18.06.1998, p. 114-117.

Research output: Contribution to journalConference Contribution

TY - JOUR

T1 - Non-invasive optical interrogation of the ocular anterior chamber

AU - Blue, Robert

AU - Uttamchandani, Deepak

AU - Wilson, Clive

PY - 1998/6/18

Y1 - 1998/6/18

N2 - Ophthalmic drug research and ocular diagnostics is hampered by an inability to perform continuous sampling of the aqueous humor contained within the anterior chamber by paracentesis is technically problematic and is associated with the use of local or general anesthesia. Moreover, sampling by direct injection exposes the eye to the risk of infection. We report results obtained from an optical instrumentation technique which is concerned with the direct and non-invasive measurements of optical scattering, absorbance and fluorescence produced in the aqueous humor by various compounds, thus avoiding the need for direct sampling. Light scatter in the anterior chamber arises from particulate matter, such as cell debris and chemical precipitates following eye surgery. Absorbance is caused by the presence of materials such as haemoglobin, or results from the penetration of drugs such as hydroxyquinolines applied to the cornea. Fluorescence can be used to provide a sensitive measurements of fluoroquinolines in the anterior chamber.

AB - Ophthalmic drug research and ocular diagnostics is hampered by an inability to perform continuous sampling of the aqueous humor contained within the anterior chamber by paracentesis is technically problematic and is associated with the use of local or general anesthesia. Moreover, sampling by direct injection exposes the eye to the risk of infection. We report results obtained from an optical instrumentation technique which is concerned with the direct and non-invasive measurements of optical scattering, absorbance and fluorescence produced in the aqueous humor by various compounds, thus avoiding the need for direct sampling. Light scatter in the anterior chamber arises from particulate matter, such as cell debris and chemical precipitates following eye surgery. Absorbance is caused by the presence of materials such as haemoglobin, or results from the penetration of drugs such as hydroxyquinolines applied to the cornea. Fluorescence can be used to provide a sensitive measurements of fluoroquinolines in the anterior chamber.

KW - non-invasive

KW - noninvasive

KW - optical interrogation

KW - ocular anterior chamber

KW - scattering

KW - surgery

KW - absorbance

KW - chemical compounds

KW - chemicals

KW - cornea

KW - diagnostics

KW - eye

KW - luminescence

KW - ophthalmology

U2 - 10.1117/12.309653

DO - 10.1117/12.309653

M3 - Conference Contribution

VL - 3483

SP - 114

EP - 117

JO - Proceedings of SPIE

T2 - Proceedings of SPIE

JF - Proceedings of SPIE

SN - 0277-786X

ER -