Non-equilibrium cobalt(iii) "click" capsules

P. R. Symmers; M. J. Burke; D. P. August; P. I T Thomson; G. S. Nichol; M. R. Warren; C. J. Campbell; P. J. Lusby

doi:10.1039/c4sc03036b

Non-equilibrium cobalt(iii) "click" capsules

P. R. Symmers, M. J. Burke, D. P. August, P. I T Thomson, G. S. Nichol, M. R. Warren, C. J. Campbell, P. J. Lusby^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Cobalt(III) tetrahedral capsules have been prepared using an assembly-followed-by-oxidation protocol from a cobalt(II) precursor and a readily derivatizable pyridyl-triazole ligand system. Experiments designed to probe the constitutional dynamics show that these architectures are in a non-equilibrium state. A preliminary investigation into the host–guest chemistry of a water-soluble derivative shows it can bind and differentiate a range of different neutral organic molecules. The stability of this ensemble also permits the study of guest-binding at high salt concentrations.

Original language	English
Pages (from-to)	756-760
Number of pages	5
Journal	Chemical Science
Volume	6
Issue number	1
DOIs	https://doi.org/10.1039/c4sc03036b
Publication status	Published - 7 Oct 2014
Externally published	Yes

Keywords

cobalt(iii)
molecular container species
drug delivery

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10.1039/c4sc03036bLicence: CC BY 3.0

Symmers-etal-CS-2014-Non-equilibrium-cobalt-iiiFinal published version, 369 KBLicence: CC BY 3.0

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abstract = "Cobalt(III) tetrahedral capsules have been prepared using an assembly-followed-by-oxidation protocol from a cobalt(II) precursor and a readily derivatizable pyridyl-triazole ligand system. Experiments designed to probe the constitutional dynamics show that these architectures are in a non-equilibrium state. A preliminary investigation into the host–guest chemistry of a water-soluble derivative shows it can bind and differentiate a range of different neutral organic molecules. The stability of this ensemble also permits the study of guest-binding at high salt concentrations.",

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AU - Symmers, P. R.

AU - Burke, M. J.

AU - August, D. P.

AU - Thomson, P. I T

AU - Nichol, G. S.

AU - Warren, M. R.

AU - Campbell, C. J.

AU - Lusby, P. J.

PY - 2014/10/7

Y1 - 2014/10/7

N2 - Cobalt(III) tetrahedral capsules have been prepared using an assembly-followed-by-oxidation protocol from a cobalt(II) precursor and a readily derivatizable pyridyl-triazole ligand system. Experiments designed to probe the constitutional dynamics show that these architectures are in a non-equilibrium state. A preliminary investigation into the host–guest chemistry of a water-soluble derivative shows it can bind and differentiate a range of different neutral organic molecules. The stability of this ensemble also permits the study of guest-binding at high salt concentrations.

AB - Cobalt(III) tetrahedral capsules have been prepared using an assembly-followed-by-oxidation protocol from a cobalt(II) precursor and a readily derivatizable pyridyl-triazole ligand system. Experiments designed to probe the constitutional dynamics show that these architectures are in a non-equilibrium state. A preliminary investigation into the host–guest chemistry of a water-soluble derivative shows it can bind and differentiate a range of different neutral organic molecules. The stability of this ensemble also permits the study of guest-binding at high salt concentrations.

KW - cobalt(iii)

KW - molecular container species

KW - drug delivery

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VL - 6

SP - 756

EP - 760

JO - Chemical Science

JF - Chemical Science

IS - 1

ER -

Non-equilibrium cobalt(iii) "click" capsules

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Keywords

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