RATS bearing NMDA lesions of the lateral hypothalamus (LH) were tested for their reactions to alterations in the sensory (but not calorific) content of the diet (finickiness), to 24 h food or water deprivation, and to dehydrating injections of hypertonic saline and glucoprivic injections.of 2-deoxy-D-glucose (2-DG). Lesioned rats lost weight following surgery but had no significant eating or drinking difficulties in the home cage. They were not finicky and responded normally to 24 h food or water deprivation. Responses to hypertonic saline and 2-DG challenges were significantly impaired. These data suggest a subtle motivational disorder following LH lesion, rather than motor or sensory impairment. © Lippincott-Raven Publishers.
- diet adulteration
- lateral hypothalamus
- physiological challenge
Clark, A. J. M., Clark, J. M., & Winn, P. (1990). NMDA lesions of rat lateral hypothalamus: effects of dietary and physiological challenges. NeuroReport, 1(3), 263-266. https://doi.org/10.1097/00001756-199011000-00024