NMDA lesions of rat lateral hypothalamus: effects of dietary and physiological challenges

Andrew J.M. Clark, Judith M. Clark, Philip Winn

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

RATS bearing NMDA lesions of the lateral hypothalamus (LH) were tested for their reactions to alterations in the sensory (but not calorific) content of the diet (finickiness), to 24 h food or water deprivation, and to dehydrating injections of hypertonic saline and glucoprivic injections.of 2-deoxy-D-glucose (2-DG). Lesioned rats lost weight following surgery but had no significant eating or drinking difficulties in the home cage. They were not finicky and responded normally to 24 h food or water deprivation. Responses to hypertonic saline and 2-DG challenges were significantly impaired. These data suggest a subtle motivational disorder following LH lesion, rather than motor or sensory impairment. © Lippincott-Raven Publishers.
LanguageEnglish
Pages263-266
Number of pages4
JournalNeuroReport
Volume1
Issue number3
DOIs
Publication statusPublished - 31 Dec 1990

Fingerprint

Lateral Hypothalamic Area
Water Deprivation
Food Deprivation
Deoxyglucose
N-Methylaspartate
Injections
Drinking
Eating
Diet
Weights and Measures

Keywords

  • deprivation
  • diet adulteration
  • drinking
  • eating
  • lateral hypothalamus
  • motivation
  • physiological challenge

Cite this

Clark, Andrew J.M. ; Clark, Judith M. ; Winn, Philip. / NMDA lesions of rat lateral hypothalamus : effects of dietary and physiological challenges. In: NeuroReport. 1990 ; Vol. 1, No. 3. pp. 263-266.
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NMDA lesions of rat lateral hypothalamus : effects of dietary and physiological challenges. / Clark, Andrew J.M.; Clark, Judith M.; Winn, Philip.

In: NeuroReport, Vol. 1, No. 3, 31.12.1990, p. 263-266.

Research output: Contribution to journalArticle

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