NMDA lesions of rat lateral hypothalamus: effects of dietary and physiological challenges

Andrew J.M. Clark, Judith M. Clark, Philip Winn

Research output: Contribution to journalArticle

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Abstract

RATS bearing NMDA lesions of the lateral hypothalamus (LH) were tested for their reactions to alterations in the sensory (but not calorific) content of the diet (finickiness), to 24 h food or water deprivation, and to dehydrating injections of hypertonic saline and glucoprivic injections.of 2-deoxy-D-glucose (2-DG). Lesioned rats lost weight following surgery but had no significant eating or drinking difficulties in the home cage. They were not finicky and responded normally to 24 h food or water deprivation. Responses to hypertonic saline and 2-DG challenges were significantly impaired. These data suggest a subtle motivational disorder following LH lesion, rather than motor or sensory impairment. © Lippincott-Raven Publishers.
Original languageEnglish
Pages (from-to)263-266
Number of pages4
JournalNeuroReport
Volume1
Issue number3
DOIs
Publication statusPublished - 31 Dec 1990

Keywords

  • deprivation
  • diet adulteration
  • drinking
  • eating
  • lateral hypothalamus
  • motivation
  • physiological challenge

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