Nickel-promoted recognition of long DNA sites by designed peptide derivatives

Jéssica Rodríguez, Jesús Mosquera, M. Eugenio Vázquez, José L. Mascareñas

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We describe the synthesis of designed peptidic modules that self-assemble in specific DNA sequences of 12 base pairs in the presence of NiIIsalts. The modules consist of modified fragments of transcription factors that have been appropriately engineered to include metal-chelating His and bipyridine ligands.

Original languageEnglish
Pages (from-to)13474-13477
Number of pages4
JournalChemistry - A European Journal
Volume22
Issue number38
DOIs
Publication statusPublished - 3 Aug 2016

Keywords

  • DNA recognition
  • metallosupramolecular chemistry
  • minor groove binder
  • peptides
  • self-assembly

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