New strategies for synergistic zinc in organometallic chemistry: rational design of bimetallic reagents in synthesis and applications

Research output: Contribution to journalLiterature review

Abstract

Pioneered by Wanklyn more than 150 years ago, organozincates have recently emerged as a versatile and regioselective type of organometallic reagents. Exhibiting unique chemical profiles, different to those observed for the monometallic components from which they are derived, these mixed-metal species offer a tremendous potential in synthesis. This article focuses on recent advances made in our research group investigating the use of these reagents in three fundamental types of organic transformations, namely, metalation, metal-halogen exchange and nucleophilic addition reactions. Through the isolation and characterization of key organometallic intermediates, the origins of their special synergic behaviour and the mechanisms involved in these reactions will also be discussed.
Translated title of the contributionNew strategies for synergistic zinc in organometallic chemistry: rational design of bimetallic reagents in synthesis and applications
LanguageSpanish
Pages335-342
Number of pages8
JournalAnales de Quimica
Volume104
Issue number4
Publication statusPublished - Dec 2011

Fingerprint

Organometallics
Zinc
Metals
Addition reactions
Halogens
Ion exchange

Keywords

  • reactivity
  • organometallic chemistry

Cite this

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title = "Nuevas estrategias sin{\'e}rgicas en qu{\'i}mica organomet{\'a}lica de Zinc: dise{\~n}o racional de reactivos bimet{\'a}licos y sus aplicaciones en s{\'i}ntesis",
abstract = "Pioneered by Wanklyn more than 150 years ago, organozincates have recently emerged as a versatile and regioselective type of organometallic reagents. Exhibiting unique chemical profiles, different to those observed for the monometallic components from which they are derived, these mixed-metal species offer a tremendous potential in synthesis. This article focuses on recent advances made in our research group investigating the use of these reagents in three fundamental types of organic transformations, namely, metalation, metal-halogen exchange and nucleophilic addition reactions. Through the isolation and characterization of key organometallic intermediates, the origins of their special synergic behaviour and the mechanisms involved in these reactions will also be discussed.",
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author = "Eva Hevia",
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AB - Pioneered by Wanklyn more than 150 years ago, organozincates have recently emerged as a versatile and regioselective type of organometallic reagents. Exhibiting unique chemical profiles, different to those observed for the monometallic components from which they are derived, these mixed-metal species offer a tremendous potential in synthesis. This article focuses on recent advances made in our research group investigating the use of these reagents in three fundamental types of organic transformations, namely, metalation, metal-halogen exchange and nucleophilic addition reactions. Through the isolation and characterization of key organometallic intermediates, the origins of their special synergic behaviour and the mechanisms involved in these reactions will also be discussed.

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