New sesquiterpene quinols from a Micronesian sponge, Aka sp

Venugopal J R V Mukku; Ruangelie Edrada-Ebel; Francis J Schmitz; Michelle Kelly Shanks; Babathosh Chaudhuri; Doriano Fabbro

doi:10.1021/np0205506

New sesquiterpene quinols from a Micronesian sponge, Aka sp

Venugopal J R V Mukku, Ruangelie Edrada-Ebel, Francis J Schmitz, Michelle Kelly Shanks, Babathosh Chaudhuri, Doriano Fabbro

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article

33 Citations (Scopus)

Abstract

Three new sesquiterpene quinols (1, 2, and 5) and two known ones (3 and 4) were isolated along with halistanol sulfate (6) from a marine sponge of the genus Aka collected from Yap Island, Federated States of Micronesia. Their structures were determined from spectral data, and the structure of siphonodictyal C (3) was revised. Sulfates 3 and 6 inhibit CDK4/cyclin D1 complexation, whereas 1 and 4 do not.

Original language	English
Pages (from-to)	686-689
Number of pages	4
Journal	Journal of Natural Products
Volume	66
Issue number	5
Early online date	25 Apr 2003
DOIs	https://doi.org/10.1021/np0205506
Publication status	Published - May 2003

Keywords

animals
chromatography, high pressure liquid
cyclin D1
cyclin dependent kinase 4
cyclin dependent kinases
inhibitory concentration 50
micronesia
molecular structure
biomolecular nuclear magnetic resonance
porifera
proto-oncogene proteins
sesquiterpenes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/np0205506

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abstract = "Three new sesquiterpene quinols (1, 2, and 5) and two known ones (3 and 4) were isolated along with halistanol sulfate (6) from a marine sponge of the genus Aka collected from Yap Island, Federated States of Micronesia. Their structures were determined from spectral data, and the structure of siphonodictyal C (3) was revised. Sulfates 3 and 6 inhibit CDK4/cyclin D1 complexation, whereas 1 and 4 do not.",

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year = "2003",

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doi = "10.1021/np0205506",

language = "English",

volume = "66",

pages = "686--689",

journal = "Journal of Natural Products",

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AU - Mukku, Venugopal J R V

AU - Edrada-Ebel, Ruangelie

AU - Schmitz, Francis J

AU - Shanks, Michelle Kelly

AU - Chaudhuri, Babathosh

AU - Fabbro, Doriano

PY - 2003/5

Y1 - 2003/5

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AB - Three new sesquiterpene quinols (1, 2, and 5) and two known ones (3 and 4) were isolated along with halistanol sulfate (6) from a marine sponge of the genus Aka collected from Yap Island, Federated States of Micronesia. Their structures were determined from spectral data, and the structure of siphonodictyal C (3) was revised. Sulfates 3 and 6 inhibit CDK4/cyclin D1 complexation, whereas 1 and 4 do not.

KW - animals

KW - chromatography, high pressure liquid

KW - cyclin D1

KW - cyclin dependent kinase 4

KW - cyclin dependent kinases

KW - inhibitory concentration 50

KW - micronesia

KW - molecular structure

KW - biomolecular nuclear magnetic resonance

KW - porifera

KW - proto-oncogene proteins

KW - sesquiterpenes

U2 - 10.1021/np0205506

DO - 10.1021/np0205506

M3 - Article

C2 - 12762808

SN - 0163-3864

VL - 66

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EP - 689

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 5

ER -

New sesquiterpene quinols from a Micronesian sponge, Aka sp

Abstract

Keywords

UN SDGs

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