New sesquiterpene quinols from a Micronesian sponge, Aka sp

Venugopal J R V Mukku, Ruangelie Edrada-Ebel, Francis J Schmitz, Michelle Kelly Shanks, Babathosh Chaudhuri, Doriano Fabbro

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Abstract

Three new sesquiterpene quinols (1, 2, and 5) and two known ones (3 and 4) were isolated along with halistanol sulfate (6) from a marine sponge of the genus Aka collected from Yap Island, Federated States of Micronesia. Their structures were determined from spectral data, and the structure of siphonodictyal C (3) was revised. Sulfates 3 and 6 inhibit CDK4/cyclin D1 complexation, whereas 1 and 4 do not.

Original languageEnglish
Pages (from-to)686-689
Number of pages4
JournalJournal of Natural Products
Volume66
Issue number5
Early online date25 Apr 2003
DOIs
Publication statusPublished - May 2003

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Keywords

  • animals
  • chromatography, high pressure liquid
  • cyclin D1
  • cyclin dependent kinase 4
  • cyclin dependent kinases
  • inhibitory concentration 50
  • micronesia
  • molecular structure
  • biomolecular nuclear magnetic resonance
  • porifera
  • proto-oncogene proteins
  • sesquiterpenes

Cite this

Mukku, V. J. R. V., Edrada-Ebel, R., Schmitz, F. J., Shanks, M. K., Chaudhuri, B., & Fabbro, D. (2003). New sesquiterpene quinols from a Micronesian sponge, Aka sp. Journal of Natural Products, 66(5), 686-689. https://doi.org/10.1021/np0205506