New roles for endosomes

from vesicular carriers to multi-purpose platforms

Gwyn W. Gould, Jennifer Lippincott-Schwartz

Research output: Contribution to journalReview article

145 Citations (Scopus)

Abstract

The careful sorting and recycling of membranes and cargo and the intracellular delivery of proteins, toxins and viruses by endocytosis are well-established roles for the endocytic apparatus, which is present in all eukaryotic cells. Recently, it has become clear that endosomes have key roles in such diverse processes as cytokinesis, polarization and migration, in which their functions might be distinct from those classically associated with endosomes. We speculate that endosomes function as multifunctional platforms on which unique sets of molecular machines are assembled to suit different cellular roles.

Original languageEnglish
Pages (from-to)287-292
Number of pages6
JournalNature Reviews Molecular Cell Biology
Volume10
Issue number4
DOIs
Publication statusPublished - 11 Mar 2009

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Endosomes
Intracellular Membranes
Cytokinesis
Eukaryotic Cells
Endocytosis
Viruses
Proteins

Keywords

  • endosomes
  • vesicular carriers

Cite this

Gould, G. W., & Lippincott-Schwartz, J. (2009). New roles for endosomes: from vesicular carriers to multi-purpose platforms. Nature Reviews Molecular Cell Biology, 10(4), 287-292. https://doi.org/10.1038/nrm2652
Gould, Gwyn W. ; Lippincott-Schwartz, Jennifer. / New roles for endosomes : from vesicular carriers to multi-purpose platforms. In: Nature Reviews Molecular Cell Biology. 2009 ; Vol. 10, No. 4. pp. 287-292.
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Gould, GW & Lippincott-Schwartz, J 2009, 'New roles for endosomes: from vesicular carriers to multi-purpose platforms', Nature Reviews Molecular Cell Biology, vol. 10, no. 4, pp. 287-292. https://doi.org/10.1038/nrm2652

New roles for endosomes : from vesicular carriers to multi-purpose platforms. / Gould, Gwyn W.; Lippincott-Schwartz, Jennifer.

In: Nature Reviews Molecular Cell Biology, Vol. 10, No. 4, 11.03.2009, p. 287-292.

Research output: Contribution to journalReview article

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Gould GW, Lippincott-Schwartz J. New roles for endosomes: from vesicular carriers to multi-purpose platforms. Nature Reviews Molecular Cell Biology. 2009 Mar 11;10(4):287-292. https://doi.org/10.1038/nrm2652