TY - JOUR
T1 - New roles for endosomes
T2 - from vesicular carriers to multi-purpose platforms
AU - Gould, Gwyn W.
AU - Lippincott-Schwartz, Jennifer
PY - 2009/3/11
Y1 - 2009/3/11
N2 - The careful sorting and recycling of membranes and cargo and the intracellular delivery of proteins, toxins and viruses by endocytosis are well-established roles for the endocytic apparatus, which is present in all eukaryotic cells. Recently, it has become clear that endosomes have key roles in such diverse processes as cytokinesis, polarization and migration, in which their functions might be distinct from those classically associated with endosomes. We speculate that endosomes function as multifunctional platforms on which unique sets of molecular machines are assembled to suit different cellular roles.
AB - The careful sorting and recycling of membranes and cargo and the intracellular delivery of proteins, toxins and viruses by endocytosis are well-established roles for the endocytic apparatus, which is present in all eukaryotic cells. Recently, it has become clear that endosomes have key roles in such diverse processes as cytokinesis, polarization and migration, in which their functions might be distinct from those classically associated with endosomes. We speculate that endosomes function as multifunctional platforms on which unique sets of molecular machines are assembled to suit different cellular roles.
KW - endosomes
KW - vesicular carriers
UR - http://www.scopus.com/inward/record.url?scp=62849097694&partnerID=8YFLogxK
U2 - 10.1038/nrm2652
DO - 10.1038/nrm2652
M3 - Review article
C2 - 19277045
AN - SCOPUS:62849097694
SN - 1759-5029
VL - 10
SP - 287
EP - 292
JO - Nature Reviews Molecular Cell Biology
JF - Nature Reviews Molecular Cell Biology
IS - 4
ER -