New probes and optical spectroscopies for immune parasitological applications

Research output: Contribution to journalArticle

Abstract

The advent of monoclonal antibody technology in the 1970s heralded a massive expansion in immunological research and provided the tools linked to optical spectroscopies to rapidly and accurately diagnose disease, localize targets, phenotype cells, deplete cell populations, purify cell populations, and quantify physiological and immunological mediators. However, there is always a demand for the development of new ultra sensitive, ultra specific, and more flexible high throughput technologies. This requires either utilizing more refined and powerful probes than monoclonal antibodies to bind to targets, or using new more sensitive optical spectroscopies to localize and quantify readouts from the signals generated following binding, or a combination of both of these factors. Aptamers (= to fit), first described in 1990 (1,2) as a substitute for antibodies, may be the ideal tools to fulfil the first requirement. However, their use in immunoparasitological systems remains limited and awaits further exploitation.
LanguageEnglish
Pages236-237
Number of pages1
JournalParasite Immunology
Volume28
Issue number6
DOIs
Publication statusPublished - 2006

Fingerprint

Spectrum Analysis
Technology
Population
Monoclonal Antibodies
Phenotype
Antibodies

Keywords

  • optical spectroscopies
  • immune parasites
  • immunology
  • pharmacology

Cite this

@article{594d312e63994d8fa7bad61b60e302bb,
title = "New probes and optical spectroscopies for immune parasitological applications",
abstract = "The advent of monoclonal antibody technology in the 1970s heralded a massive expansion in immunological research and provided the tools linked to optical spectroscopies to rapidly and accurately diagnose disease, localize targets, phenotype cells, deplete cell populations, purify cell populations, and quantify physiological and immunological mediators. However, there is always a demand for the development of new ultra sensitive, ultra specific, and more flexible high throughput technologies. This requires either utilizing more refined and powerful probes than monoclonal antibodies to bind to targets, or using new more sensitive optical spectroscopies to localize and quantify readouts from the signals generated following binding, or a combination of both of these factors. Aptamers (= to fit), first described in 1990 (1,2) as a substitute for antibodies, may be the ideal tools to fulfil the first requirement. However, their use in immunoparasitological systems remains limited and awaits further exploitation.",
keywords = "optical spectroscopies, immune parasites, immunology, pharmacology",
author = "J. Alexander and D. Graham",
year = "2006",
doi = "10.1111/j.1365-3024.2006.00841.x",
language = "English",
volume = "28",
pages = "236--237",
journal = "Parasite Immunology",
issn = "0141-9838",
number = "6",

}

New probes and optical spectroscopies for immune parasitological applications. / Alexander, J.; Graham, D.

In: Parasite Immunology, Vol. 28, No. 6, 2006, p. 236-237.

Research output: Contribution to journalArticle

TY - JOUR

T1 - New probes and optical spectroscopies for immune parasitological applications

AU - Alexander, J.

AU - Graham, D.

PY - 2006

Y1 - 2006

N2 - The advent of monoclonal antibody technology in the 1970s heralded a massive expansion in immunological research and provided the tools linked to optical spectroscopies to rapidly and accurately diagnose disease, localize targets, phenotype cells, deplete cell populations, purify cell populations, and quantify physiological and immunological mediators. However, there is always a demand for the development of new ultra sensitive, ultra specific, and more flexible high throughput technologies. This requires either utilizing more refined and powerful probes than monoclonal antibodies to bind to targets, or using new more sensitive optical spectroscopies to localize and quantify readouts from the signals generated following binding, or a combination of both of these factors. Aptamers (= to fit), first described in 1990 (1,2) as a substitute for antibodies, may be the ideal tools to fulfil the first requirement. However, their use in immunoparasitological systems remains limited and awaits further exploitation.

AB - The advent of monoclonal antibody technology in the 1970s heralded a massive expansion in immunological research and provided the tools linked to optical spectroscopies to rapidly and accurately diagnose disease, localize targets, phenotype cells, deplete cell populations, purify cell populations, and quantify physiological and immunological mediators. However, there is always a demand for the development of new ultra sensitive, ultra specific, and more flexible high throughput technologies. This requires either utilizing more refined and powerful probes than monoclonal antibodies to bind to targets, or using new more sensitive optical spectroscopies to localize and quantify readouts from the signals generated following binding, or a combination of both of these factors. Aptamers (= to fit), first described in 1990 (1,2) as a substitute for antibodies, may be the ideal tools to fulfil the first requirement. However, their use in immunoparasitological systems remains limited and awaits further exploitation.

KW - optical spectroscopies

KW - immune parasites

KW - immunology

KW - pharmacology

UR - http://dx.doi.org/10.1111/j.1365-3024.2006.00841.x

U2 - 10.1111/j.1365-3024.2006.00841.x

DO - 10.1111/j.1365-3024.2006.00841.x

M3 - Article

VL - 28

SP - 236

EP - 237

JO - Parasite Immunology

T2 - Parasite Immunology

JF - Parasite Immunology

SN - 0141-9838

IS - 6

ER -