New perspectives on the role of sphingosine 1-phosphate in cancer

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

13 Citations (Scopus)

Abstract

In this chapter, we review the latest developments concerning the role of sphingosine 1-phosphate (S1P) in cancer. Particular focus is paid to the role of sphingosine kinases 1 and 2, S1P lyase and S1P-dependent signalling networks in both solid tumours and haematological cancer. The potential of this S1P-dependent pathophysiology as a therapeutic target for the treatment of cancer is also discussed.
Original languageEnglish
Title of host publicationSphingolipids in Disease
EditorsErich Gulbins, Irina Petrache
Place of PublicationVienna
PublisherSpringer-Verlag
Pages55-71
Number of pages17
ISBN (Print)9783709115107
DOIs
Publication statusPublished - 31 Mar 2013

Publication series

NameHandbook of experimental pharmacology
PublisherSpringer Verlag
Number216
ISSN (Print)0171-2004

Keywords

  • sphingosine 1-phosphate in
  • cancer
  • new perspectives
  • sphingosine kinase
  • ceramide
  • infectious disease
  • sphingolipids

Cite this

Pyne, S., & Pyne, N. (2013). New perspectives on the role of sphingosine 1-phosphate in cancer. In E. Gulbins, & I. Petrache (Eds.), Sphingolipids in Disease (pp. 55-71). (Handbook of experimental pharmacology ; No. 216). Springer-Verlag. https://doi.org/10.1007/978-3-7091-1511-4_3