New perspectives on the role of sphingosine 1-phosphate in cancer

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

15 Citations (Scopus)


In this chapter, we review the latest developments concerning the role of sphingosine 1-phosphate (S1P) in cancer. Particular focus is paid to the role of sphingosine kinases 1 and 2, S1P lyase and S1P-dependent signalling networks in both solid tumours and haematological cancer. The potential of this S1P-dependent pathophysiology as a therapeutic target for the treatment of cancer is also discussed.
Original languageEnglish
Title of host publicationSphingolipids in Disease
EditorsErich Gulbins, Irina Petrache
Place of PublicationVienna
Number of pages17
ISBN (Print)9783709115107
Publication statusPublished - 31 Mar 2013

Publication series

NameHandbook of experimental pharmacology
PublisherSpringer Verlag
ISSN (Print)0171-2004


  • sphingosine 1-phosphate in
  • cancer
  • new perspectives
  • sphingosine kinase
  • ceramide
  • infectious disease
  • sphingolipids


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