New oxygenated sesquiterpenes from the Indonesian soft coral Nephthea chabrolii

D. Handayani; R. A. Edrada; P. Proksch; V. Wray; L. Witte; L. Van Ofwegen; A. Kunzmann

doi:10.1021/np960699f

New oxygenated sesquiterpenes from the Indonesian soft coral Nephthea chabrolii

D. Handayani, R. A. Edrada, P. Proksch^*, V. Wray, L. Witte, L. Van Ofwegen, A. Kunzmann

^*Corresponding author for this work

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

The Indonesian soft coral Nephthea chabrolii afforded two new oxygenated sesquiterpenes: hydroxycolorenone (1) and methexycolorenone (2), as well as the known liverwort metabolite (+)-cyclocolorenone (3). This is the first report of the occurrence of such terrestrial liverwort metabolites in marine soft corals. The structures of the new compounds were unambiguously established on the basis of NMR spectroscopic data ( ¹H, ¹³C, COSY, ¹H- detected direct and long-range ¹³C- ¹H correlations). Compound 1 exhibited insecticidal activity towards neonate larvae of the polyphagous pest insect Spodoptera littoralis, with an EC ₅₀ of 8.8 ppm and a LC ₅₀ of 453 ppm, when incorporated in artificial diet and offered to larvae in a chronic feeding bioassay.

Original language	English
Pages (from-to)	716-718
Number of pages	3
Journal	Journal of Natural Products
Volume	60
Issue number	7
DOIs	https://doi.org/10.1021/np960699f
Publication status	Published - 22 Jul 1997

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 14 Life Below Water

Keywords

Indonesian soft coral
Nephthea chabrolii
xygenated sesquiterpenes
marine soft corals

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10.1021/np960699f

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title = "New oxygenated sesquiterpenes from the Indonesian soft coral Nephthea chabrolii",

abstract = "The Indonesian soft coral Nephthea chabrolii afforded two new oxygenated sesquiterpenes: hydroxycolorenone (1) and methexycolorenone (2), as well as the known liverwort metabolite (+)-cyclocolorenone (3). This is the first report of the occurrence of such terrestrial liverwort metabolites in marine soft corals. The structures of the new compounds were unambiguously established on the basis of NMR spectroscopic data ( 1H, 13C, COSY, 1H- detected direct and long-range 13C- 1H correlations). Compound 1 exhibited insecticidal activity towards neonate larvae of the polyphagous pest insect Spodoptera littoralis, with an EC 50 of 8.8 ppm and a LC 50 of 453 ppm, when incorporated in artificial diet and offered to larvae in a chronic feeding bioassay.",

keywords = "Indonesian soft coral, Nephthea chabrolii, xygenated sesquiterpenes, marine soft corals",

author = "D. Handayani and Edrada, \{R. A.\} and P. Proksch and V. Wray and L. Witte and \{Van Ofwegen\}, L. and A. Kunzmann",

year = "1997",

month = jul,

day = "22",

doi = "10.1021/np960699f",

language = "English",

volume = "60",

pages = "716--718",

journal = "Journal of Natural Products",

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T1 - New oxygenated sesquiterpenes from the Indonesian soft coral Nephthea chabrolii

AU - Handayani, D.

AU - Edrada, R. A.

AU - Proksch, P.

AU - Wray, V.

AU - Witte, L.

AU - Van Ofwegen, L.

AU - Kunzmann, A.

PY - 1997/7/22

Y1 - 1997/7/22

N2 - The Indonesian soft coral Nephthea chabrolii afforded two new oxygenated sesquiterpenes: hydroxycolorenone (1) and methexycolorenone (2), as well as the known liverwort metabolite (+)-cyclocolorenone (3). This is the first report of the occurrence of such terrestrial liverwort metabolites in marine soft corals. The structures of the new compounds were unambiguously established on the basis of NMR spectroscopic data ( 1H, 13C, COSY, 1H- detected direct and long-range 13C- 1H correlations). Compound 1 exhibited insecticidal activity towards neonate larvae of the polyphagous pest insect Spodoptera littoralis, with an EC 50 of 8.8 ppm and a LC 50 of 453 ppm, when incorporated in artificial diet and offered to larvae in a chronic feeding bioassay.

AB - The Indonesian soft coral Nephthea chabrolii afforded two new oxygenated sesquiterpenes: hydroxycolorenone (1) and methexycolorenone (2), as well as the known liverwort metabolite (+)-cyclocolorenone (3). This is the first report of the occurrence of such terrestrial liverwort metabolites in marine soft corals. The structures of the new compounds were unambiguously established on the basis of NMR spectroscopic data ( 1H, 13C, COSY, 1H- detected direct and long-range 13C- 1H correlations). Compound 1 exhibited insecticidal activity towards neonate larvae of the polyphagous pest insect Spodoptera littoralis, with an EC 50 of 8.8 ppm and a LC 50 of 453 ppm, when incorporated in artificial diet and offered to larvae in a chronic feeding bioassay.

KW - Indonesian soft coral

KW - Nephthea chabrolii

KW - xygenated sesquiterpenes

KW - marine soft corals

UR - https://www.scopus.com/pages/publications/0030872444

U2 - 10.1021/np960699f

DO - 10.1021/np960699f

M3 - Article

AN - SCOPUS:0030872444

SN - 0163-3864

VL - 60

SP - 716

EP - 718

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 7

ER -

New oxygenated sesquiterpenes from the Indonesian soft coral Nephthea chabrolii

Abstract

UN SDGs

Keywords

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