New metabolites from sponge-derived fungi Curvularia lunata and Cladosporium herbarum

Raquel Jadulco, Gernot Brauers, Ruangelie Edrada-Ebel, Rainer Ebel, Victor Wray, Peter Proksch

Research output: Contribution to journalArticle

110 Citations (Scopus)


The fungus Curvularia lunata, isolated from the marine sponge Niphates olemda, yielded the new 1,3,8-trihydroxy-6-methoxyanthraquinone, which we named lunatin (1), the known modified bisanthraquinone cytoskyrin A (2), and the known plant hormone (+)-abscisic acid (3). Both anthraquinones were found to be active against Bacillus subtilis, Staphylococcus aureus, and Escherichia coli. Two strains of the fungus Cladosporium herbarum, isolated from the sponges Aplysina aerophoba and Callyspongia aerizusa, respectively, yielded two new alpha-pyrones, herbarin A (4) and herbarin B (5), the known compound citreoviridin A (6), and the new phthalide herbaric acid (7). All structures were unambiguously established by 1D and 2D NMR and MS data.

Original languageEnglish
Pages (from-to)730-733
Number of pages4
JournalJournal of Natural Products
Issue number5
Early online date2 Apr 2002
Publication statusPublished - May 2002


  • abscisic acid
  • animals
  • anthraquinones
  • anti-bacterial agents
  • anti-infective agents
  • antifungal agents
  • artemia
  • bacillus subtilis
  • candida albicans
  • thin layer chromatography
  • escherichia coli
  • feeding behavior
  • fungi
  • Indonesia
  • Mediterranean sea
  • molecular structure
  • nuclear magnetic resonance, biomolecular
  • Porifera
  • Spodoptera
  • staphylococcus aureus


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