Abstract
| Language | English |
|---|---|
| Pages | 4-6 |
| Number of pages | 3 |
| Journal | Journal of Pathology |
| Volume | 233 |
| Issue number | 1 |
| Early online date | 12 Apr 2014 |
| DOIs | |
| Publication status | Published - May 2014 |
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Keywords
- zDHHC
- DHHC
- S-acylation
- palmitoylation
- cancer
Cite this
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New links between S-acylation and cancer. / Greaves, Jennifer; Chamberlain, Luke.
In: Journal of Pathology, Vol. 233, No. 1, 05.2014, p. 4-6.Research output: Contribution to journal › Literature review
TY - JOUR
T1 - New links between S-acylation and cancer
AU - Greaves, Jennifer
AU - Chamberlain, Luke
PY - 2014/5
Y1 - 2014/5
N2 - S-acylation (also known as palmitoylation) is a major post-translational protein modification in all eukaryotic cells, involving the attachment of fatty acids onto cysteine residues. A variety of structural and signalling proteins are modified in this way, affecting their stability, membrane association and intracellular targeting. The enzymes that mediate S-acylation are encoded by genes belonging to the large (> 20 genes) ZDHHC family. The importance of these enzymes for normal physiological function is highlighted by their links to a diverse range of disease states, including neurological disorders, such as Huntington's disease, schizophrenia and intellectual disability, and diabetes and cancer. The recent study by Yeste-Velasco et al published in the Journal of Pathology highlights a novel tumour suppressor function for the zDHHC family: expression of zDHHC14 is decreased in testicular germ cell tumours, prostate cancer and a variety of other cancer types. This important finding further emphasizes the emerging clinical significance of the zDHHC family of S-acylation enzymes.
AB - S-acylation (also known as palmitoylation) is a major post-translational protein modification in all eukaryotic cells, involving the attachment of fatty acids onto cysteine residues. A variety of structural and signalling proteins are modified in this way, affecting their stability, membrane association and intracellular targeting. The enzymes that mediate S-acylation are encoded by genes belonging to the large (> 20 genes) ZDHHC family. The importance of these enzymes for normal physiological function is highlighted by their links to a diverse range of disease states, including neurological disorders, such as Huntington's disease, schizophrenia and intellectual disability, and diabetes and cancer. The recent study by Yeste-Velasco et al published in the Journal of Pathology highlights a novel tumour suppressor function for the zDHHC family: expression of zDHHC14 is decreased in testicular germ cell tumours, prostate cancer and a variety of other cancer types. This important finding further emphasizes the emerging clinical significance of the zDHHC family of S-acylation enzymes.
KW - zDHHC
KW - DHHC
KW - S-acylation
KW - palmitoylation
KW - cancer
U2 - 10.1002/path.4339
DO - 10.1002/path.4339
M3 - Literature review
VL - 233
SP - 4
EP - 6
JO - Journal of Pathology
T2 - Journal of Pathology
JF - Journal of Pathology
SN - 0022-3417
IS - 1
ER -