New links between S-acylation and cancer

Jennifer Greaves, Luke Chamberlain

Research output: Contribution to journalLiterature review

18 Citations (Scopus)

Abstract

S-acylation (also known as palmitoylation) is a major post-translational protein modification in all eukaryotic cells, involving the attachment of fatty acids onto cysteine residues. A variety of structural and signalling proteins are modified in this way, affecting their stability, membrane association and intracellular targeting. The enzymes that mediate S-acylation are encoded by genes belonging to the large (> 20 genes) ZDHHC family. The importance of these enzymes for normal physiological function is highlighted by their links to a diverse range of disease states, including neurological disorders, such as Huntington's disease, schizophrenia and intellectual disability, and diabetes and cancer. The recent study by Yeste-Velasco et al published in the Journal of Pathology highlights a novel tumour suppressor function for the zDHHC family: expression of zDHHC14 is decreased in testicular germ cell tumours, prostate cancer and a variety of other cancer types. This important finding further emphasizes the emerging clinical significance of the zDHHC family of S-acylation enzymes.
LanguageEnglish
Pages4-6
Number of pages3
JournalJournal of Pathology
Volume233
Issue number1
Early online date12 Apr 2014
DOIs
Publication statusPublished - May 2014

Fingerprint

Acylation
Enzymes
Lipoylation
Neoplasms
Intracellular Membranes
Huntington Disease
Eukaryotic Cells
Post Translational Protein Processing
Nervous System Diseases
Intellectual Disability
Genes
Cysteine
Prostatic Neoplasms
Schizophrenia
Fatty Acids
Pathology
Proteins

Keywords

  • zDHHC
  • DHHC
  • S-acylation
  • palmitoylation
  • cancer

Cite this

Greaves, Jennifer ; Chamberlain, Luke. / New links between S-acylation and cancer. In: Journal of Pathology. 2014 ; Vol. 233, No. 1. pp. 4-6.
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New links between S-acylation and cancer. / Greaves, Jennifer; Chamberlain, Luke.

In: Journal of Pathology, Vol. 233, No. 1, 05.2014, p. 4-6.

Research output: Contribution to journalLiterature review

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T1 - New links between S-acylation and cancer

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AU - Chamberlain, Luke

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AB - S-acylation (also known as palmitoylation) is a major post-translational protein modification in all eukaryotic cells, involving the attachment of fatty acids onto cysteine residues. A variety of structural and signalling proteins are modified in this way, affecting their stability, membrane association and intracellular targeting. The enzymes that mediate S-acylation are encoded by genes belonging to the large (> 20 genes) ZDHHC family. The importance of these enzymes for normal physiological function is highlighted by their links to a diverse range of disease states, including neurological disorders, such as Huntington's disease, schizophrenia and intellectual disability, and diabetes and cancer. The recent study by Yeste-Velasco et al published in the Journal of Pathology highlights a novel tumour suppressor function for the zDHHC family: expression of zDHHC14 is decreased in testicular germ cell tumours, prostate cancer and a variety of other cancer types. This important finding further emphasizes the emerging clinical significance of the zDHHC family of S-acylation enzymes.

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