New imidazole alkaloids from the Indonesian sponge Leucetta chagosensis

Wafaa Hassan, RuAngelie Edrada, Rainer Ebel, Victor Wray, Albrecht Berg, Rob van Soest, Sumali Wiryowidagdo, Peter Proksch, Ruangelie Edrada-Ebel

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79 Citations (Scopus)

Abstract

Chemical investigation of the sponge Leucetta chagosensis collected in Indonesia afforded five new imidazole alkaloids, naamine F (2), naamine G (3), kealiinine A (6), kealiinine B (7), and kealiinine C (8), in addition to the known compound naamine A (1). Naamine G (3) exhibited strong antifungal activity against the phytopathogenic fungus Cladosporium herbarum and also showed mild cytotoxicity against mouse lymphoma (L5178Y) and human cervix carcinoma (HeLa) cell lines. In the brine shrimp assay, kealiinine A (6) was more active than naamine G (3). The structures of the new compounds were unambiguously established by 1D and 2D NMR and MS data.

Original languageEnglish
Pages (from-to)817-822
Number of pages6
JournalJournal of Natural Products
Volume67
Issue number5
DOIs
Publication statusPublished - May 2004

Keywords

  • alkaloids
  • antifungal agents
  • antineoplastic agents
  • artemia
  • cladosporium
  • drug screening assays
  • imidazoles
  • Indonesia
  • mass spectrometry
  • microbial sensitivity tests
  • molecular structure
  • nuclear magnetic resonance
  • porifera
  • tumor cells

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  • Cite this

    Hassan, W., Edrada, R., Ebel, R., Wray, V., Berg, A., van Soest, R., Wiryowidagdo, S., Proksch, P., & Edrada-Ebel, R. (2004). New imidazole alkaloids from the Indonesian sponge Leucetta chagosensis. Journal of Natural Products, 67(5), 817-822. https://doi.org/10.1021/np0305223