New imidazole alkaloids from the Indonesian sponge Leucetta chagosensis

Wafaa Hassan; RuAngelie Edrada; Rainer Ebel; Victor Wray; Albrecht Berg; Rob van Soest; Sumali Wiryowidagdo; Peter Proksch; Ruangelie Edrada-Ebel

doi:10.1021/np0305223

New imidazole alkaloids from the Indonesian sponge Leucetta chagosensis

Wafaa Hassan, RuAngelie Edrada, Rainer Ebel, Victor Wray, Albrecht Berg, Rob van Soest, Sumali Wiryowidagdo, Peter Proksch, Ruangelie Edrada-Ebel

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article

93 Citations (Scopus)

Abstract

Chemical investigation of the sponge Leucetta chagosensis collected in Indonesia afforded five new imidazole alkaloids, naamine F (2), naamine G (3), kealiinine A (6), kealiinine B (7), and kealiinine C (8), in addition to the known compound naamine A (1). Naamine G (3) exhibited strong antifungal activity against the phytopathogenic fungus Cladosporium herbarum and also showed mild cytotoxicity against mouse lymphoma (L5178Y) and human cervix carcinoma (HeLa) cell lines. In the brine shrimp assay, kealiinine A (6) was more active than naamine G (3). The structures of the new compounds were unambiguously established by 1D and 2D NMR and MS data.

Original language	English
Pages (from-to)	817-822
Number of pages	6
Journal	Journal of Natural Products
Volume	67
Issue number	5
DOIs	https://doi.org/10.1021/np0305223
Publication status	Published - May 2004

Keywords

alkaloids
antifungal agents
antineoplastic agents
artemia
cladosporium
drug screening assays
imidazoles
Indonesia
mass spectrometry
microbial sensitivity tests
molecular structure
nuclear magnetic resonance
porifera
tumor cells

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10.1021/np0305223

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title = "New imidazole alkaloids from the Indonesian sponge Leucetta chagosensis",

abstract = "Chemical investigation of the sponge Leucetta chagosensis collected in Indonesia afforded five new imidazole alkaloids, naamine F (2), naamine G (3), kealiinine A (6), kealiinine B (7), and kealiinine C (8), in addition to the known compound naamine A (1). Naamine G (3) exhibited strong antifungal activity against the phytopathogenic fungus Cladosporium herbarum and also showed mild cytotoxicity against mouse lymphoma (L5178Y) and human cervix carcinoma (HeLa) cell lines. In the brine shrimp assay, kealiinine A (6) was more active than naamine G (3). The structures of the new compounds were unambiguously established by 1D and 2D NMR and MS data.",

keywords = "alkaloids, antifungal agents, antineoplastic agents, artemia, cladosporium, drug screening assays, imidazoles, Indonesia, mass spectrometry, microbial sensitivity tests, molecular structure, nuclear magnetic resonance, porifera, tumor cells",

author = "Wafaa Hassan and RuAngelie Edrada and Rainer Ebel and Victor Wray and Albrecht Berg and {van Soest}, Rob and Sumali Wiryowidagdo and Peter Proksch and Ruangelie Edrada-Ebel",

year = "2004",

month = may,

doi = "10.1021/np0305223",

language = "English",

volume = "67",

pages = "817--822",

journal = "Journal of Natural Products",

issn = "0163-3864",

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T1 - New imidazole alkaloids from the Indonesian sponge Leucetta chagosensis

AU - Hassan, Wafaa

AU - Edrada, RuAngelie

AU - Ebel, Rainer

AU - Wray, Victor

AU - Berg, Albrecht

AU - van Soest, Rob

AU - Wiryowidagdo, Sumali

AU - Proksch, Peter

AU - Edrada-Ebel, Ruangelie

PY - 2004/5

Y1 - 2004/5

N2 - Chemical investigation of the sponge Leucetta chagosensis collected in Indonesia afforded five new imidazole alkaloids, naamine F (2), naamine G (3), kealiinine A (6), kealiinine B (7), and kealiinine C (8), in addition to the known compound naamine A (1). Naamine G (3) exhibited strong antifungal activity against the phytopathogenic fungus Cladosporium herbarum and also showed mild cytotoxicity against mouse lymphoma (L5178Y) and human cervix carcinoma (HeLa) cell lines. In the brine shrimp assay, kealiinine A (6) was more active than naamine G (3). The structures of the new compounds were unambiguously established by 1D and 2D NMR and MS data.

AB - Chemical investigation of the sponge Leucetta chagosensis collected in Indonesia afforded five new imidazole alkaloids, naamine F (2), naamine G (3), kealiinine A (6), kealiinine B (7), and kealiinine C (8), in addition to the known compound naamine A (1). Naamine G (3) exhibited strong antifungal activity against the phytopathogenic fungus Cladosporium herbarum and also showed mild cytotoxicity against mouse lymphoma (L5178Y) and human cervix carcinoma (HeLa) cell lines. In the brine shrimp assay, kealiinine A (6) was more active than naamine G (3). The structures of the new compounds were unambiguously established by 1D and 2D NMR and MS data.

KW - alkaloids

KW - antifungal agents

KW - antineoplastic agents

KW - artemia

KW - cladosporium

KW - drug screening assays

KW - imidazoles

KW - Indonesia

KW - mass spectrometry

KW - microbial sensitivity tests

KW - molecular structure

KW - nuclear magnetic resonance

KW - porifera

KW - tumor cells

U2 - 10.1021/np0305223

DO - 10.1021/np0305223

M3 - Article

C2 - 15165143

SN - 0163-3864

VL - 67

SP - 817

EP - 822

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 5

ER -

New imidazole alkaloids from the Indonesian sponge Leucetta chagosensis

Abstract

Keywords

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