New communesin derivatives from the fungus Penicillium sp. derived from the Mediterranean sponge Axinella verrucosa

Raquel Jadulco, Ru Angelie Edrada, Rainer Ebel, Albrecht Berg, Karsten Schaumann, Victor Wray, Klaus Steube, Peter Proksch, Ruangelie Edrada-Ebel

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

The ethyl acetate extract of Penicillium sp., derived from the Mediterranean sponge Axinella verrucosa, yielded the known compound communesin B (1) and its new congeners communesins C (2) and D (3), as well as the known compounds griseofulvin, dechlorogriseofulvin, and oxaline. All structures were unambiguously established by 1D and 2D NMR and MS data. In several bioassays performed on different leukemia cell lines, the communesins exhibited moderate antiproliferative activity.

Original languageEnglish
Pages (from-to)78-81
Number of pages4
JournalJournal of Natural Products
Volume67
Issue number1
DOIs
Publication statusPublished - Jan 2004

Keywords

  • Animals
  • antineoplastic agents
  • artemia
  • drug screening assays
  • griseofulvin
  • heterocyclic compounds with 4 or More Rings
  • Italy
  • Mediterranean Sea
  • molecular structure
  • nuclear magnetic resonance
  • penicillium
  • porifera
  • stereoisomerism
  • tumor cells

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