New communesin derivatives from the fungus Penicillium sp. derived from the Mediterranean sponge Axinella verrucosa

Raquel Jadulco; Ru Angelie Edrada; Rainer Ebel; Albrecht Berg; Karsten Schaumann; Victor Wray; Klaus Steube; Peter Proksch; Ruangelie Edrada-Ebel

doi:10.1021/np030271y

New communesin derivatives from the fungus Penicillium sp. derived from the Mediterranean sponge Axinella verrucosa

Raquel Jadulco, Ru Angelie Edrada, Rainer Ebel, Albrecht Berg, Karsten Schaumann, Victor Wray, Klaus Steube, Peter Proksch, Ruangelie Edrada-Ebel

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article

178 Citations (Scopus)

Abstract

The ethyl acetate extract of Penicillium sp., derived from the Mediterranean sponge Axinella verrucosa, yielded the known compound communesin B (1) and its new congeners communesins C (2) and D (3), as well as the known compounds griseofulvin, dechlorogriseofulvin, and oxaline. All structures were unambiguously established by 1D and 2D NMR and MS data. In several bioassays performed on different leukemia cell lines, the communesins exhibited moderate antiproliferative activity.

Original language	English
Pages (from-to)	78-81
Number of pages	4
Journal	Journal of Natural Products
Volume	67
Issue number	1
DOIs	https://doi.org/10.1021/np030271y
Publication status	Published - Jan 2004

Keywords

Animals
antineoplastic agents
artemia
drug screening assays
griseofulvin
heterocyclic compounds with 4 or More Rings
Italy
Mediterranean Sea
molecular structure
nuclear magnetic resonance
penicillium
porifera
stereoisomerism
tumor cells

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10.1021/np030271y

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title = "New communesin derivatives from the fungus Penicillium sp. derived from the Mediterranean sponge Axinella verrucosa",

abstract = "The ethyl acetate extract of Penicillium sp., derived from the Mediterranean sponge Axinella verrucosa, yielded the known compound communesin B (1) and its new congeners communesins C (2) and D (3), as well as the known compounds griseofulvin, dechlorogriseofulvin, and oxaline. All structures were unambiguously established by 1D and 2D NMR and MS data. In several bioassays performed on different leukemia cell lines, the communesins exhibited moderate antiproliferative activity.",

keywords = "Animals, antineoplastic agents, artemia, drug screening assays, griseofulvin, heterocyclic compounds with 4 or More Rings, Italy, Mediterranean Sea, molecular structure, nuclear magnetic resonance, penicillium, porifera, stereoisomerism, tumor cells",

author = "Raquel Jadulco and Edrada, {Ru Angelie} and Rainer Ebel and Albrecht Berg and Karsten Schaumann and Victor Wray and Klaus Steube and Peter Proksch and Ruangelie Edrada-Ebel",

year = "2004",

month = jan,

doi = "10.1021/np030271y",

language = "English",

volume = "67",

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T1 - New communesin derivatives from the fungus Penicillium sp. derived from the Mediterranean sponge Axinella verrucosa

AU - Jadulco, Raquel

AU - Edrada, Ru Angelie

AU - Ebel, Rainer

AU - Berg, Albrecht

AU - Schaumann, Karsten

AU - Wray, Victor

AU - Steube, Klaus

AU - Proksch, Peter

AU - Edrada-Ebel, Ruangelie

PY - 2004/1

Y1 - 2004/1

N2 - The ethyl acetate extract of Penicillium sp., derived from the Mediterranean sponge Axinella verrucosa, yielded the known compound communesin B (1) and its new congeners communesins C (2) and D (3), as well as the known compounds griseofulvin, dechlorogriseofulvin, and oxaline. All structures were unambiguously established by 1D and 2D NMR and MS data. In several bioassays performed on different leukemia cell lines, the communesins exhibited moderate antiproliferative activity.

AB - The ethyl acetate extract of Penicillium sp., derived from the Mediterranean sponge Axinella verrucosa, yielded the known compound communesin B (1) and its new congeners communesins C (2) and D (3), as well as the known compounds griseofulvin, dechlorogriseofulvin, and oxaline. All structures were unambiguously established by 1D and 2D NMR and MS data. In several bioassays performed on different leukemia cell lines, the communesins exhibited moderate antiproliferative activity.

KW - Animals

KW - antineoplastic agents

KW - artemia

KW - drug screening assays

KW - griseofulvin

KW - heterocyclic compounds with 4 or More Rings

KW - Italy

KW - Mediterranean Sea

KW - molecular structure

KW - nuclear magnetic resonance

KW - penicillium

KW - porifera

KW - stereoisomerism

KW - tumor cells

U2 - 10.1021/np030271y

DO - 10.1021/np030271y

M3 - Article

C2 - 14738391

SN - 0163-3864

VL - 67

SP - 78

EP - 81

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 1

ER -

New communesin derivatives from the fungus Penicillium sp. derived from the Mediterranean sponge Axinella verrucosa

Abstract

Keywords

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