New bromopyrrole alkaloids from the marine sponges axinella damicornis and stylissa flabelliformis

Wafaa Hassan, Ehab S. Elkhayat, Ru AnGelie Edrada, Rainer Ebel, Peter Proksch

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Abstract

Investigation of the tropical sponges Axinella damicornis and Stylissa flabelliformis, family Axinillidae, afforded five new bromopyrrole alkaloids (1-5) and thirteen known compounds (6-18). Semi synthesis of S was carried out in order to confirm its structure. The structures of the isolated compounds were elucidated using ID- And 2D-NMR spectroscopy and mass spectrometry. The cytotoxicity, antimicrobial and protein-kinase inhibition activities were tested for the isolated compounds.

Original languageEnglish
Pages (from-to)1149-1154
Number of pages6
JournalNatural Product Communications
Volume2
Issue number11
Publication statusPublished - 2007

Keywords

  • axinella damicornis
  • axinillidae
  • bromopyrroles
  • stylissa flabelliformis

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