New anti-trypanosomal active prenylated compounds from African propolis

Sultan Almutairi; Ben Eapen; Sai Maneesha Chundi; Adnan Akhalil; Weam Siheri; Carol Clements; James Fearnley; David G. Watson; Ruangelie Edrada-Ebel

doi:10.1016/j.phytol.2014.07.002

New anti-trypanosomal active prenylated compounds from African propolis

Sultan Almutairi, Ben Eapen, Sai Maneesha Chundi, Adnan Akhalil, Weam Siheri, Carol Clements, James Fearnley, David G. Watson^*, Ruangelie Edrada-Ebel

^*Corresponding author for this work

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

The secondary metabolite composition of propolis has always been corroborated on the vegetation surrounding the bee hive. The plants chosen by the bees seem to exhibit activity to protect the hive from the surrounding environmental pressures which include protozoal attack. Two new stilbene compounds were isolated from Ghanian propolis which were formed either via geranylation or prenylation. These compounds exhibited moderate activity against Trypanosoma brucei brucei. While a new phlorogucinonone analogue was isolated from a Cameroon propolis that was found to possess high potency comparable to that of suramin.

Original language	English
Pages (from-to)	35-39
Number of pages	5
Journal	Phytochemistry Letters
Volume	10
Early online date	23 Jul 2014
DOIs	https://doi.org/10.1016/j.phytol.2014.07.002
Publication status	Published - 31 Dec 2014

Keywords

antitrypanosomal activity
geranylated stilbene
HRESIMS
NMR
prenylated propolone
propolis

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10.1016/j.phytol.2014.07.002

Cite this

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title = "New anti-trypanosomal active prenylated compounds from African propolis",

abstract = "The secondary metabolite composition of propolis has always been corroborated on the vegetation surrounding the bee hive. The plants chosen by the bees seem to exhibit activity to protect the hive from the surrounding environmental pressures which include protozoal attack. Two new stilbene compounds were isolated from Ghanian propolis which were formed either via geranylation or prenylation. These compounds exhibited moderate activity against Trypanosoma brucei brucei. While a new phlorogucinonone analogue was isolated from a Cameroon propolis that was found to possess high potency comparable to that of suramin. ",

keywords = "antitrypanosomal activity, geranylated stilbene, HRESIMS, NMR, prenylated propolone, propolis",

author = "Sultan Almutairi and Ben Eapen and Chundi, {Sai Maneesha} and Adnan Akhalil and Weam Siheri and Carol Clements and James Fearnley and Watson, {David G.} and Ruangelie Edrada-Ebel",

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doi = "10.1016/j.phytol.2014.07.002",

language = "English",

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T1 - New anti-trypanosomal active prenylated compounds from African propolis

AU - Almutairi, Sultan

AU - Eapen, Ben

AU - Chundi, Sai Maneesha

AU - Akhalil, Adnan

AU - Siheri, Weam

AU - Clements, Carol

AU - Fearnley, James

AU - Watson, David G.

AU - Edrada-Ebel, Ruangelie

PY - 2014/12/31

Y1 - 2014/12/31

N2 - The secondary metabolite composition of propolis has always been corroborated on the vegetation surrounding the bee hive. The plants chosen by the bees seem to exhibit activity to protect the hive from the surrounding environmental pressures which include protozoal attack. Two new stilbene compounds were isolated from Ghanian propolis which were formed either via geranylation or prenylation. These compounds exhibited moderate activity against Trypanosoma brucei brucei. While a new phlorogucinonone analogue was isolated from a Cameroon propolis that was found to possess high potency comparable to that of suramin.

AB - The secondary metabolite composition of propolis has always been corroborated on the vegetation surrounding the bee hive. The plants chosen by the bees seem to exhibit activity to protect the hive from the surrounding environmental pressures which include protozoal attack. Two new stilbene compounds were isolated from Ghanian propolis which were formed either via geranylation or prenylation. These compounds exhibited moderate activity against Trypanosoma brucei brucei. While a new phlorogucinonone analogue was isolated from a Cameroon propolis that was found to possess high potency comparable to that of suramin.

KW - antitrypanosomal activity

KW - geranylated stilbene

KW - HRESIMS

KW - NMR

KW - prenylated propolone

KW - propolis

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DO - 10.1016/j.phytol.2014.07.002

M3 - Article

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SN - 1874-3900

VL - 10

SP - 35

EP - 39

JO - Phytochemistry Letters

JF - Phytochemistry Letters

ER -

New anti-trypanosomal active prenylated compounds from African propolis

Abstract

Keywords

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New anti-trypanosomal active prenylated compounds from African propolis

Abstract

Keywords

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Datasets

Libyan propolis raw data

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