New 9-thiocyanatopupukeanane sesquiterpenes from the nudibranch Phyllidia varicosa and its sponge-prey Axinyssa aculeata

Yasman Yasman, Ru Angelie Edrada, Victor Wray, Peter Proksch, Ruangelie Edrada-Ebel

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Two new 9-thiocyanatopupukeanane sesquiterpene isomers were isolated as major metabolites from the MeOH extract of the sponge Axinyssa aculeata and from its nudibranch predator Phyllidia varicosa. The presence of the sesquiterpenes was monitored by GC-MS, and the structures were confirmed by both 1D and 2D NMR spectroscopy. The isolated sesquiterpenes were found to be toxic toward brine shrimp at LC(50) of 5 ppm. At a dose level of 20 microg, they were found to be weakly and moderately active against B. subtilis and C. albicans, respectively.

Original languageEnglish
Pages (from-to)1512-1514
Number of pages3
JournalJournal of Natural Products
Volume66
Issue number11
DOIs
Publication statusPublished - Nov 2003

Keywords

  • animals
  • Artemia
  • bacillus subtilis
  • candida albicans
  • escherichia coli
  • Indonesia
  • microbial sensitivity tests
  • molecular structure
  • mollusca
  • nuclear magnetic resonance
  • porifera
  • sesquiterpenes
  • staphylococcus aureus

Fingerprint Dive into the research topics of 'New 9-thiocyanatopupukeanane sesquiterpenes from the nudibranch Phyllidia varicosa and its sponge-prey Axinyssa aculeata'. Together they form a unique fingerprint.

  • Cite this