TY - JOUR
T1 - Neutrophil to lymphocyte ratio and in-hospital mortality among patients with SARSCoV-2
T2 - a retrospective study
AU - Al-Mazedi, Maryam Salah
AU - Rajan, Rajesh
AU - Al-Jarallah, Mohammed
AU - Dashti, Raja
AU - Al Saber, Ahmad
AU - Pan, Jiazhu
AU - Zhanna, Kobalava D.
AU - Abdelnaby, Hassan
AU - Aboelhassan, Wael
AU - Almutairi, Farah
AU - Alotaibi, Naser
AU - Al Saleh, Mohammad
AU - AlNasrallah, Noor
AU - Al-Bader, Bader
AU - Malhas, Haya
AU - Ramadhan, Maryam
AU - A. Brady, Peter
AU - Al-Zakwani, Ibrahim
AU - Setiya, Parul
AU - Abdullah, Mohammed
AU - Alroomi, Moudhi
AU - Tse, Gary
PY - 2022/10/4
Y1 - 2022/10/4
N2 - The goal of this study was to investigate in-hospital mortality in patients suffering from acute respiratory syndrome coronavirus 2 (SARS-CoV-2) relative to the neutrophil to lymphocyte ratio (NLR) and to determine if there are gender disparities in outcome. Between February 26 and September 8, 2020, patients having SARS-CoV-2 infection were enrolled in this retrospective cohort research, which was categorized by NLR levels ≥9 and < 9. In total, 6893 patients were involved included of whom6591 had NLR <9, and 302 had NLR ≥9. The age of most of the patients in the NLR<9 group was 50 years, on the other hand, the age of most of the NLR ≥9 group patients was between 50 and 70 years. The majority of patients in both groups were male 2211 (66.1%). The ICU admission time and mortality rate for the patients with NLR ≥9 was significantly higher compared to patients with NLR <9. Logistic regression's outcome indicated that NLR ≥9 (odds ratio (OR), 24.9; 95% confidence interval (CI): 15.5–40.0; p < 0.001), male sex (OR, 3.5; 95% CI: 2.0–5.9; p < 0.001) and haemoglobin (HB) (OR, 0.95; 95% CI; 0.94–0.96; p < 0.001) predicted in-hospital mortality significantly. Additionally, Cox proportional hazards analysis (B = 4.04, SE = 0.18, HR = 56.89, p < 0.001) and Kaplan–Meier survival probability plots also indicated that NLR>9 had a significant effect on mortality. NLR ≥9 is an independent predictor of mortality(in-hospital) among SARS-CoV-2 patients.
AB - The goal of this study was to investigate in-hospital mortality in patients suffering from acute respiratory syndrome coronavirus 2 (SARS-CoV-2) relative to the neutrophil to lymphocyte ratio (NLR) and to determine if there are gender disparities in outcome. Between February 26 and September 8, 2020, patients having SARS-CoV-2 infection were enrolled in this retrospective cohort research, which was categorized by NLR levels ≥9 and < 9. In total, 6893 patients were involved included of whom6591 had NLR <9, and 302 had NLR ≥9. The age of most of the patients in the NLR<9 group was 50 years, on the other hand, the age of most of the NLR ≥9 group patients was between 50 and 70 years. The majority of patients in both groups were male 2211 (66.1%). The ICU admission time and mortality rate for the patients with NLR ≥9 was significantly higher compared to patients with NLR <9. Logistic regression's outcome indicated that NLR ≥9 (odds ratio (OR), 24.9; 95% confidence interval (CI): 15.5–40.0; p < 0.001), male sex (OR, 3.5; 95% CI: 2.0–5.9; p < 0.001) and haemoglobin (HB) (OR, 0.95; 95% CI; 0.94–0.96; p < 0.001) predicted in-hospital mortality significantly. Additionally, Cox proportional hazards analysis (B = 4.04, SE = 0.18, HR = 56.89, p < 0.001) and Kaplan–Meier survival probability plots also indicated that NLR>9 had a significant effect on mortality. NLR ≥9 is an independent predictor of mortality(in-hospital) among SARS-CoV-2 patients.
KW - NLR
KW - covid-19
KW - in-hospital mortality
KW - SARS CoV-2
U2 - 10.1016/j.amsu.2022.104748
DO - 10.1016/j.amsu.2022.104748
M3 - Article
SN - 2049-0801
VL - 82
JO - Annals of Medicine and Surgery
JF - Annals of Medicine and Surgery
M1 - 104748
ER -
