Neurological injury during cardiopulmonary bypass in the rat

    Research output: Contribution to journalArticle

    41 Citations (Scopus)

    Abstract

    Cerebral injury is a well-known complication of cardiac surgery. Investigations of both injury mechanisms and neuroprotective strategies have partially been limited by the lack of an adequate preclinical model of small animal cardiopulmonary bypass (CPB). We sought to determine if neurological injury could be demonstrated in a recovery model of complete CPB in the rat. Rats (n = 5) underwent 45 min of normothermic CPB followed by 24 h of recovery. Compared to sham-operated rats (n = 5), the CPB group showed a worse neurological outcome score (median, 25-75th percentile) compared to controls (5, 4-7 vs 9, 8-9, p = 0.016). This rat model of CPB may allow for the study of CPB-associated neurological injury.
    LanguageEnglish
    Pages75-81
    Number of pages6
    JournalPerfusion
    Volume16
    Issue number1
    DOIs
    Publication statusPublished - 2001

    Fingerprint

    Cardiopulmonary Bypass
    Rats
    Wounds and Injuries
    Recovery
    surgery
    animal
    Surgery
    Animals
    lack
    Thoracic Surgery
    Animal Models
    Group

    Keywords

    • neurology
    • injury
    • cardiopulmonary bypass
    • rat
    • perfusion

    Cite this

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    Neurological injury during cardiopulmonary bypass in the rat. / Gourlay, T.

    In: Perfusion, Vol. 16, No. 1, 2001, p. 75-81.

    Research output: Contribution to journalArticle

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