Neuroinflammation and cerebrovascular disease in old age: a translational medicine perspective

Mario Di Napoli, Imtiaz M. Shah

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The incidence of cerebrovascular disease is highest in the elderly population. However, the pathophysiological mechanisms of brain response to cerebral ischemia in old age are currently poorly understood. Ischemic changes in the commonly used young animal stroke models do not reflect the molecular changes associated with the aged brain. Neuroinflammation and oxidative stress are important pathogenic processes occurring during the acute phase of cerebral ischemia. Free radical generation is also implicated in the aging process, and the combination of these effects in elderly stroke patients could explain the higher risk of morbidity and mortality. A better understanding of stroke pathophysiology in the elderly patient would assist in the development of new therapeutic strategies for this vulnerable age group. With the increasing use of reperfusion therapies, inflammatory pathways and oxidative stress remain attractive therapeutic targets for the development of adjuvant neuroprotective agents. This paper will discuss these molecular aspects of acute stroke and senescence from a bench-to-bedside research perspective.
LanguageEnglish
Article number857484
Pages1-18
Number of pages18
JournalJournal of Aging Research
Volume2011
DOIs
Publication statusPublished - 2011

Fingerprint

Cerebrovascular Disorders
Translational Medical Research
Stroke
Brain Ischemia
Oxidative Stress
Brain
Neuroprotective Agents
Reperfusion
Free Radicals
Therapeutics
Animal Models
Age Groups
Morbidity
Mortality
Incidence
Research
Population

Keywords

  • cerebrovascular disease
  • brain response
  • cerebral ischemia

Cite this

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Neuroinflammation and cerebrovascular disease in old age : a translational medicine perspective. / Di Napoli, Mario; Shah, Imtiaz M.

In: Journal of Aging Research, Vol. 2011, 857484, 2011, p. 1-18.

Research output: Contribution to journalArticle

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