Neuroanatomical correlates of neuropsychiatric symptoms in Alzheimer's disease

Peita D. Bruen, William J. McGeown, Michael F. Shanks, Annalena Venneri

Research output: Contribution to journalArticle

205 Citations (Scopus)

Abstract

Alzheimer's disease research has largely concentrated on the study of cognitive decline, but the associated behavioural and neuropsychiatric symptoms are of equal importance in the clinical profile of the disease. There is emerging evidence that regional differences in brain atrophy may align with variant disease presentations. The objective of this study was to identify the regions of decreased grey matter (GM) volume which were associated with specific neuropsychiatric behaviours in patients with mild Alzheimer's disease. Voxel-based morphometry was used to correlate GM derived from T(1)-weighted MRI images of 31 patients with mild Alzheimer's disease and specific neuropsychiatric symptoms and behaviours measured by the Neuropsychiatric Inventory. Delusions were associated with decreased GM density in the left frontal lobe, in the right frontoparietal cortex and in the left claustrum. Apathy was associated with GM density loss in the anterior cingulate and frontal cortex bilaterally, the head of the left caudate nucleus and in bilateral putamen. Agitation was associated with decreased GM values in the left insula, and in anterior cingulate cortex bilaterally. Neuropsychiatric symptoms of Alzheimer's disease seem to associate with neurodegeneration of specific neural networks supporting personal memory, reality monitoring, processing of reward, interoceptive sensations and subjective emotional experience. The study of neurodegenerative disorders such as Alzheimer's disease using voxel-based morphometry and other imaging modalities may further the understanding of the neural structures that mediate the genesis of abnormal behaviours.

LanguageEnglish
Pages2455-2463
Number of pages9
JournalBrain
Volume131
Issue number9
Early online date11 Jul 2008
DOIs
Publication statusPublished - Sep 2008

Fingerprint

Alzheimer Disease
Gyrus Cinguli
Frontal Lobe
Apathy
Behavioral Symptoms
Delusions
Caudate Nucleus
Putamen
Basal Ganglia
Reward
Neurodegenerative Diseases
Atrophy
Gray Matter
Equipment and Supplies
Brain
Research

Keywords

  • mild cognitive impairment
  • dementia
  • prefrontal cortex
  • voxel-based morphometry
  • delusions
  • apathy
  • MRI
  • agitation

Cite this

Bruen, Peita D. ; McGeown, William J. ; Shanks, Michael F. ; Venneri, Annalena. / Neuroanatomical correlates of neuropsychiatric symptoms in Alzheimer's disease. In: Brain. 2008 ; Vol. 131, No. 9. pp. 2455-2463.
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Neuroanatomical correlates of neuropsychiatric symptoms in Alzheimer's disease. / Bruen, Peita D.; McGeown, William J.; Shanks, Michael F.; Venneri, Annalena.

In: Brain, Vol. 131, No. 9, 09.2008, p. 2455-2463.

Research output: Contribution to journalArticle

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