Projects per year
Abstract
Difluorovinylmetal building blocks prepd. from 1-(2'-methoxy-ethoxymethoxy) -2,2,2-trifluoroethane (1a) and 1-(N,N-diethylcarbamoyloxy)-2,2,2-trifluoroethane (1b), have been used in our lab. in syntheses of analogs of biol. significant compds. Access to these useful reagents requires a dehydrofluorination/metalation step at -78°C; however, the seminal work of Donald Burton and co-workers have allowed us to prep. difluorovinylzinc reagents 2a and 2b and iodides 3a and 3b at near ambient temp. and investigate their scope in palladium catalyzed coupling.
Original language | English |
---|---|
Article number | FLUO-65 |
Journal | Abstracts of papers - American Chemical Society |
Volume | 242 |
Publication status | Published - 28 Aug 2011 |
Event | 242nd National Meeting of the American-Chemical-Society (ACS) - Denver, United States Duration: 28 Aug 2011 → 1 Sept 2011 |
Keywords
- trifluoroethanol
- difluoroenol derivatives
- dehydrofluorination
- metalation
- negishi coupling
- metallated difluoroenol derivatives
- trifluoroethanol
Fingerprint
Dive into the research topics of 'Negishi coupling of metallated difluoroenol derivatives based on trifluoroethanol'. Together they form a unique fingerprint.Projects
- 1 Finished