Negishi coupling of metallated difluoroenol derivatives based on trifluoroethanol

Peter Wilson, Jonathan M. Percy, Joanna M. Redmond

Research output: Contribution to journalMeeting abstract

Abstract

Difluorovinylmetal building blocks prepd. from 1-(2'-methoxy-ethoxymethoxy) -2,2,2-trifluoroethane (1a) and 1-(N,N-diethylcarbamoyloxy)-2,2,2-trifluoroethane (1b), have been used in our lab. in syntheses of analogs of biol. significant compds. Access to these useful reagents requires a dehydrofluorination/metalation step at -78°C; however, the seminal work of Donald Burton and co-workers have allowed us to prep. difluorovinylzinc reagents 2a and 2b and iodides 3a and 3b at near ambient temp. and investigate their scope in palladium catalyzed coupling.
Original languageEnglish
Article numberFLUO-65
JournalAbstracts of papers - American Chemical Society
Volume242
Publication statusPublished - 28 Aug 2011
Event242nd National Meeting of the American-Chemical-Society (ACS) - Denver, United States
Duration: 28 Aug 20111 Sep 2011

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Keywords

  • trifluoroethanol
  • difluoroenol derivatives
  • dehydrofluorination
  • metalation
  • negishi coupling
  • metallated difluoroenol derivatives
  • trifluoroethanol

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