Negative symptoms and psychosocial functioning in schizophrenia: neglected but important targets for treatment

R. Hunter, S.J.E. Barry

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Background: Many patients with schizophrenia suffer from poor social functioning, with high levels of unemployment being one particular consequence. Negative symptoms tend to persist during periods of clinical stability and may have a detrimental effect on function. This paper aims to investigate the relationship between negative symptoms and ability to function.

Methods: The EGOFORS study measured negative symptoms in 295 schizophrenia patients in 11 European sites using the PANSS Negative Subscale and assessment scales for psychosocial function: Global Assessment of Functioning (GAF), Personal and Social Performance (PSP), Quality of Life Scale (QLS), Functional Remission of General Schizophrenia (FROGS), Psychosocial Remission in Schizophrenia (PSRS) and Subjective Wellbeing under Neuroleptics (SWN). The relationships between the PANSS Negative Subscale and the functional scales were investigated, adjusting for differences between study sites. Being in work, duration of illness, age of onset and number of years of education were also investigated for a relationship with function.

Results: There were strong, statistically significant correlations between PANSS Negative Subscale and all of the function scales (95% confidence intervals for the correlation coefficients: PSRS 0.77?0.91; FROGS 0.74?0.89; QLS 0.74?0.92; GAF 0.64?0.78; PSP 0.63?0.80) except the SWN. All of the functional scales except SWN were at least moderately related to one another. All of the items in each of the PANSS Negative Subscale and the function scales contributed to the relationships between them. Better functioning correlated strongly with participants being in work.

Conclusion: This study shows a strong and significant relationship between negative symptoms and psychosocial functioning. Given the impact of negative symptoms on psychosocial function, much more emphasis should be placed on developing effective treatments for negative symptoms, given that most patients with schizophrenia now live in community settings and require to function adequately to support their quality of life.

LanguageEnglish
Pages432-436
Number of pages5
JournalEuropean Psychiatry
Volume27
Issue number6
DOIs
Publication statusPublished - 1 Aug 2012

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Schizophrenia
Antipsychotic Agents
Quality of Life
Therapeutics
Aptitude
Unemployment
Age of Onset
Confidence Intervals
Education

Keywords

  • schizophrenia
  • cognitive disorders
  • psychosocial functioning
  • drug target

Cite this

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abstract = "Background: Many patients with schizophrenia suffer from poor social functioning, with high levels of unemployment being one particular consequence. Negative symptoms tend to persist during periods of clinical stability and may have a detrimental effect on function. This paper aims to investigate the relationship between negative symptoms and ability to function. Methods: The EGOFORS study measured negative symptoms in 295 schizophrenia patients in 11 European sites using the PANSS Negative Subscale and assessment scales for psychosocial function: Global Assessment of Functioning (GAF), Personal and Social Performance (PSP), Quality of Life Scale (QLS), Functional Remission of General Schizophrenia (FROGS), Psychosocial Remission in Schizophrenia (PSRS) and Subjective Wellbeing under Neuroleptics (SWN). The relationships between the PANSS Negative Subscale and the functional scales were investigated, adjusting for differences between study sites. Being in work, duration of illness, age of onset and number of years of education were also investigated for a relationship with function. Results: There were strong, statistically significant correlations between PANSS Negative Subscale and all of the function scales (95{\%} confidence intervals for the correlation coefficients: PSRS 0.77?0.91; FROGS 0.74?0.89; QLS 0.74?0.92; GAF 0.64?0.78; PSP 0.63?0.80) except the SWN. All of the functional scales except SWN were at least moderately related to one another. All of the items in each of the PANSS Negative Subscale and the function scales contributed to the relationships between them. Better functioning correlated strongly with participants being in work. Conclusion: This study shows a strong and significant relationship between negative symptoms and psychosocial functioning. Given the impact of negative symptoms on psychosocial function, much more emphasis should be placed on developing effective treatments for negative symptoms, given that most patients with schizophrenia now live in community settings and require to function adequately to support their quality of life.",
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Negative symptoms and psychosocial functioning in schizophrenia : neglected but important targets for treatment. / Hunter, R.; Barry, S.J.E.

In: European Psychiatry, Vol. 27, No. 6, 01.08.2012, p. 432-436.

Research output: Contribution to journalArticle

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T1 - Negative symptoms and psychosocial functioning in schizophrenia

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AU - Barry, S.J.E.

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AB - Background: Many patients with schizophrenia suffer from poor social functioning, with high levels of unemployment being one particular consequence. Negative symptoms tend to persist during periods of clinical stability and may have a detrimental effect on function. This paper aims to investigate the relationship between negative symptoms and ability to function. Methods: The EGOFORS study measured negative symptoms in 295 schizophrenia patients in 11 European sites using the PANSS Negative Subscale and assessment scales for psychosocial function: Global Assessment of Functioning (GAF), Personal and Social Performance (PSP), Quality of Life Scale (QLS), Functional Remission of General Schizophrenia (FROGS), Psychosocial Remission in Schizophrenia (PSRS) and Subjective Wellbeing under Neuroleptics (SWN). The relationships between the PANSS Negative Subscale and the functional scales were investigated, adjusting for differences between study sites. Being in work, duration of illness, age of onset and number of years of education were also investigated for a relationship with function. Results: There were strong, statistically significant correlations between PANSS Negative Subscale and all of the function scales (95% confidence intervals for the correlation coefficients: PSRS 0.77?0.91; FROGS 0.74?0.89; QLS 0.74?0.92; GAF 0.64?0.78; PSP 0.63?0.80) except the SWN. All of the functional scales except SWN were at least moderately related to one another. All of the items in each of the PANSS Negative Subscale and the function scales contributed to the relationships between them. Better functioning correlated strongly with participants being in work. Conclusion: This study shows a strong and significant relationship between negative symptoms and psychosocial functioning. Given the impact of negative symptoms on psychosocial function, much more emphasis should be placed on developing effective treatments for negative symptoms, given that most patients with schizophrenia now live in community settings and require to function adequately to support their quality of life.

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KW - cognitive disorders

KW - psychosocial functioning

KW - drug target

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SP - 432

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JO - European Psychiatry

JF - European Psychiatry

SN - 0924-9338

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