Near-infrared spectroscopy study of tourniquet-induced forearm ischaemia in patients with coronary artery disease

Mario Ettore Giardini, Giovanni G. Guizzetti, Matteo Bavera, Paolo Lago, Mario Corti, Colomba Falcone, Federico Pastore

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

1 Citation (Scopus)
45 Downloads (Pure)

Abstract

Near-Infrared Spectroscopy (NIRS) can be employed to monitor local changes in haemodynamics and oxygenation of human tissues. A preliminary study has been performed in order to evaluate the NIRS transmittance response to induced forearm ischaemia in patients with coronary artery disease (CAD). The population consists in 40 patients with cardiovascular risk factors and angiographically documented CAD, compared to a group of 13 normal subjects. By inflating and subsequently deflating a cuff placed around the patient arm, an ischaemia has been induced and released, and the patients have been observed until recovery of the basal conditions. A custom NIRS spectrometer (IRIS) has been used to collect the backscattered light intensities from the patient forearm throughout the ischaemic and the recovery phase. The time dependence of the near-infrared transmittance on the control group is consistent with the available literature. On the contrary, the magnitude and dynamics of the NIRS signal on the CAD patients show deviations from the documented normal behavior, which can be tentatively attributed to abnormal vessel stiffness. These preliminary results, while validating the performance of the IRIS spectrometer, are strongly conducive towards the applicability of the NIRS technique to ischaemia analysis and to endothelial dysfunction characterization in CAD patients with cardiovascular risk factors.
Original languageEnglish
Title of host publicationBiomedical Diagnostic, Guidance, and Surgical-Assist Systems III
EditorsTuan Vo-Dinh, Warren S. Grundfest, David A. Benaron
Place of PublicationBellingham
Pages1-6
Number of pages6
DOIs
Publication statusPublished - 4 Jun 2001
Event3rd Conference on Biomedical Diagnostic, Guidance, and Surgical-Assist Systems - San Jose, United States
Duration: 21 Jan 200122 Jan 2001

Publication series

NameProceedings of SPIE
PublisherSPIE Press
Volume4254
ISSN (Print)0277-786X

Conference

Conference3rd Conference on Biomedical Diagnostic, Guidance, and Surgical-Assist Systems
CountryUnited States
CitySan Jose
Period21/01/0122/01/01

    Fingerprint

Keywords

  • NIRS
  • near-infrared spectroscopy
  • cardiovascular risk
  • CAD

Cite this

Giardini, M. E., Guizzetti, G. G., Bavera, M., Lago, P., Corti, M., Falcone, C., & Pastore, F. (2001). Near-infrared spectroscopy study of tourniquet-induced forearm ischaemia in patients with coronary artery disease. In T. Vo-Dinh, W. S. Grundfest, & D. A. Benaron (Eds.), Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III (pp. 1-6). (Proceedings of SPIE; Vol. 4254). Bellingham. https://doi.org/10.1117/12.427938