Natural vaccine adjuvants and immunopotentiators derived from plants, fungi, marine organisms, and insects

N. Woods, K. Niwasabutra, R. Acevedo, John Igoli, N.A. Altwaijry, J. Tusiimire, A.I. Gray, D.G. Watson, V.A. Ferro

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)

Abstract

Secondary metabolites from natural sources have made a significant contribution to medicine for millennia. In modern medicine, drugs developed from natural products have been used to treat infectious diseases, cancer, hypertension, and inflammation.1 Research on immunomodulators for application in vaccines has been sporadic, but it stands to reason that the field could better exploit the biodiversity of active compounds from natural sources. Most new chemical entities (NCE) have been inspired from plants, while microbes have also yielded a significant number of drugs.2,3 Increasingly, there are reports of NCE derived from fungi and marine sources,4,5 and animals.6 Although immunopotentiators mined from plants are well established, other organisms have also been evaluated.
Original languageEnglish
Title of host publicationImmunopotentiators in Modern Vaccines
EditorsVirgil E.J.C. Schijns, Derek T. O'Hagan
Place of PublicationLondon
Pages211-230
Number of pages20
Edition2nd
Publication statusPublished - 10 Nov 2016

Keywords

  • immunomodulators
  • vaccines
  • new chemical entities

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