Natural products as a screening resource

Research output: Contribution to journalLiterature review

143 Citations (Scopus)

Abstract

Natural products have been the most productive source of leads for new drugs, but they are currently out of fashion with the pharmaceutical industry. New approaches to sourcing novel compounds from untapped areas of biodiversity coupled with the technical advances in analytical techniques (such as microcoil NMR and linked LC-MS-NMR) have removed many of the difficulties in using natural products in screening campaigns. As the 'chemical space' occupied by natural products is both more varied and more drug-like than that of combinatorial chemical collections, synthetic and biosynthetic methods are being developed to produce screening libraries of natural product-like compounds. A renaissance of drug discovery inspired by natural products can be predicted.
Original languageEnglish
Pages (from-to)480-484
Number of pages5
JournalCurrent Opinion in Chemical Biology
Volume11
Issue number5
Early online date19 Sep 2007
DOIs
Publication statusPublished - Oct 2007

Keywords

  • biodiversity
  • biological products
  • analytical chemistry techniques
  • preclinical drug evaluation
  • drug industry

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