Nanostructured hydrogels for three-dimensional cell culture through self-assembly of fluorenylmethoxycarbonyl-dipeptides

V Jayawarna, M Ali, T A Jowitt, A E Miller, A Saiani, J E Gough, R V Ulijn

Research output: Contribution to journalArticle

728 Citations (Scopus)

Abstract

A number of short peptide amphiphiles consisting of dipeptides linked to fluorenylmethoxycarbonyl spontaneously form fibrous hydrogels under physiological conditions (see figure). The structural and physical properties of these gels are dictated by the amino acid sequence of the peptide building blocks, and the gels support the three-dimensional cell culture of chondrocytes.

Original languageEnglish
Pages (from-to)611-614
Number of pages5
JournalAdvanced Materials
Volume18
Issue number5
DOIs
Publication statusPublished - 3 Mar 2006

Keywords

  • nanostructured hydrogels
  • three-dimensional cell culture
  • fluorenylmethoxycarbonyl-dipeptides
  • self-assembly

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