Nanoparticles and inflammation

Ross Stevenson, Axel J. Hueber, Alan Hutton, Iain B. McInnes, Duncan Graham

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The development of nanoscale molecular probes capable of diagnosis, characterization, and clinical treatment of disease is leading to a new generation of imaging technologies. Such probes are particularly relevant to inflammation, where the detection of subclinical, early disease states could facilitate speedier detection that could yield enhanced, tailored therapies. Nanoparticles offer robust platforms capable of sensitive detection, and early research has indicated their suitability for the detection of vascular activation and cellular recruitment at subclinical levels. This suggests that nanoparticle techniques may provide excellent biomarkers for the diagnosis and progression of inflammatory diseases with magnetic resonance imaging (MRI), fluorescent quantum dots (QDs), and surface enhanced Raman scattering (SERS) probes being just some of the new methodologies employed. Development of these techniques could lead to a range of sensitive probes capable of ultrasensitive, localized detection of inflammation. This article will discuss the merits of each approach, with a general overview to their applicability in inflammatory diseases.

LanguageEnglish
Pages1300-1312
Number of pages13
JournalScientificWorld Journal
Volume11
DOIs
Publication statusPublished - 2011

Fingerprint

Nanoparticles
Inflammation
Molecular Probes
Quantum Dots
probe
Raman Spectrum Analysis
Blood Vessels
Disease Progression
Early Diagnosis
Biomarkers
Magnetic Resonance Imaging
Technology
Imaging techniques
Magnetic resonance
Research
Semiconductor quantum dots
Raman scattering
Chemical activation
biomarker
scattering

Keywords

  • nanoparticles
  • inflammation
  • in vivo imaging
  • raman-scattering
  • nanoparticle
  • quantum dots
  • hyperlipidemic rabbots
  • imaging inflammation
  • arthritis
  • contrast agent
  • cells
  • TIC - Bionanotechnology

Cite this

Stevenson, R., Hueber, A. J., Hutton, A., McInnes, I. B., & Graham, D. (2011). Nanoparticles and inflammation. ScientificWorld Journal, 11, 1300-1312. https://doi.org/10.1100/tsw.2011.106
Stevenson, Ross ; Hueber, Axel J. ; Hutton, Alan ; McInnes, Iain B. ; Graham, Duncan. / Nanoparticles and inflammation. In: ScientificWorld Journal. 2011 ; Vol. 11. pp. 1300-1312.
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Stevenson, R, Hueber, AJ, Hutton, A, McInnes, IB & Graham, D 2011, 'Nanoparticles and inflammation' ScientificWorld Journal, vol. 11, pp. 1300-1312. https://doi.org/10.1100/tsw.2011.106

Nanoparticles and inflammation. / Stevenson, Ross; Hueber, Axel J.; Hutton, Alan; McInnes, Iain B.; Graham, Duncan.

In: ScientificWorld Journal, Vol. 11, 2011, p. 1300-1312.

Research output: Contribution to journalArticle

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Stevenson R, Hueber AJ, Hutton A, McInnes IB, Graham D. Nanoparticles and inflammation. ScientificWorld Journal. 2011;11:1300-1312. https://doi.org/10.1100/tsw.2011.106