Nanoparticle for biomolecule delivery

Duncan Graham (Inventor), Nial Wheate (Inventor), Sarah Brown (Inventor), Gemma Craig (Inventor)

Research output: Patent

Abstract

A nanoparticle comprises a metal nanoparticle, e.g. gold, functionalised with at least one linker, the at least one linker comprising at least one first moiety capable of interacting with the metal nanoparticle, and at least one second moiety capable of interacting with at least one platinum group metal-based biologically active compound, e.g. a drug, wherein the molar ratio or capacity of platinum group metal-based biologically active compounds per nanoparticle is greater than (150). The present invention also relates to a method of preparing a nanoparticle according to the present invention. The present invention also relates to a biologically active nanoparticle comprising a nanoparticle according to the present invention, and at least one platinum group metal-based biologically active compound. The biologically active nanoparticle is more efficiently targeted to specific parts of the body, e.g. cancer cells, while reducing the side effects of the biomolecules being delivered.
Original languageEnglish
Patent numberWO2010139942
IPCA61K41/00; A61K47/48; A61P35/00
Priority date2/06/09
Publication statusPublished - 2010

Keywords

  • metal nanoparticles
  • gold
  • platinum nanoparticles

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  • Cite this

    Graham, D., Wheate, N., Brown, S., & Craig, G. (2010). IPC No. A61K41/00; A61K47/48; A61P35/00. Nanoparticle for biomolecule delivery. (Patent No. WO2010139942).