Abstract
Ultrasensitive surface bioaffinity sensors are created by the adsorption of gold nanoparticles onto gold diffraction gratings. An enhanced diffraction obtained in a surface plasmon resonance geometry is observed due to the optical coupling of the planar surface plasmons in the grating to the localized surface plasmons in the gold nanoparticles. As a first example, these nanoparticle grating biosensors are employed to detect unmodified DNA at a concentration of 10 fM.
Original language | English |
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Pages (from-to) | 6697-6701 |
Number of pages | 5 |
Journal | Analytical Chemistry |
Volume | 79 |
Issue number | 17 |
DOIs | |
Publication status | Published - 3 Aug 2007 |
Keywords
- bioaffinity sensors
- adsorption
- gold nanoparticles
- diffraction gratings
- plasmons
- unmodified DNA