Nanoparticle-enhanced diffraction gratings for ultrasensitive surface plasmon biosensing

A.W. Wark, Hye Jin Lee, A.J. Qavi, R.M. Corn

Research output: Contribution to journalArticlepeer-review

77 Citations (Scopus)


Ultrasensitive surface bioaffinity sensors are created by the adsorption of gold nanoparticles onto gold diffraction gratings. An enhanced diffraction obtained in a surface plasmon resonance geometry is observed due to the optical coupling of the planar surface plasmons in the grating to the localized surface plasmons in the gold nanoparticles. As a first example, these nanoparticle grating biosensors are employed to detect unmodified DNA at a concentration of 10 fM.
Original languageEnglish
Pages (from-to)6697-6701
Number of pages5
JournalAnalytical Chemistry
Issue number17
Publication statusPublished - 3 Aug 2007


  • bioaffinity sensors
  • adsorption
  • gold nanoparticles
  • diffraction gratings
  • plasmons
  • unmodified DNA

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