Nanoparticle-enhanced diffraction gratings for ultrasensitive surface plasmon biosensing

A.W. Wark, Hye Jin Lee, A.J. Qavi, R.M. Corn

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Ultrasensitive surface bioaffinity sensors are created by the adsorption of gold nanoparticles onto gold diffraction gratings. An enhanced diffraction obtained in a surface plasmon resonance geometry is observed due to the optical coupling of the planar surface plasmons in the grating to the localized surface plasmons in the gold nanoparticles. As a first example, these nanoparticle grating biosensors are employed to detect unmodified DNA at a concentration of 10 fM.
LanguageEnglish
Pages6697-6701
Number of pages5
JournalAnalytical Chemistry
Volume79
Issue number17
DOIs
Publication statusPublished - 3 Aug 2007

Fingerprint

Diffraction gratings
Gold
Plasmons
Nanoparticles
Surface plasmon resonance
Biosensors
Diffraction
Adsorption
Geometry
DNA
Sensors

Keywords

  • bioaffinity sensors
  • adsorption
  • gold nanoparticles
  • diffraction gratings
  • plasmons
  • unmodified DNA

Cite this

Wark, A.W. ; Lee, Hye Jin ; Qavi, A.J. ; Corn, R.M. / Nanoparticle-enhanced diffraction gratings for ultrasensitive surface plasmon biosensing. In: Analytical Chemistry. 2007 ; Vol. 79, No. 17. pp. 6697-6701.
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Nanoparticle-enhanced diffraction gratings for ultrasensitive surface plasmon biosensing. / Wark, A.W.; Lee, Hye Jin; Qavi, A.J.; Corn, R.M.

In: Analytical Chemistry, Vol. 79, No. 17, 03.08.2007, p. 6697-6701.

Research output: Contribution to journalArticle

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AU - Wark, A.W.

AU - Lee, Hye Jin

AU - Qavi, A.J.

AU - Corn, R.M.

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N2 - Ultrasensitive surface bioaffinity sensors are created by the adsorption of gold nanoparticles onto gold diffraction gratings. An enhanced diffraction obtained in a surface plasmon resonance geometry is observed due to the optical coupling of the planar surface plasmons in the grating to the localized surface plasmons in the gold nanoparticles. As a first example, these nanoparticle grating biosensors are employed to detect unmodified DNA at a concentration of 10 fM.

AB - Ultrasensitive surface bioaffinity sensors are created by the adsorption of gold nanoparticles onto gold diffraction gratings. An enhanced diffraction obtained in a surface plasmon resonance geometry is observed due to the optical coupling of the planar surface plasmons in the grating to the localized surface plasmons in the gold nanoparticles. As a first example, these nanoparticle grating biosensors are employed to detect unmodified DNA at a concentration of 10 fM.

KW - bioaffinity sensors

KW - adsorption

KW - gold nanoparticles

KW - diffraction gratings

KW - plasmons

KW - unmodified DNA

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T2 - Analytical Chemistry

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