Nanomedicine and its potential in diabetes research and practice

J.C. Pickup, Z.L. Zhi, F. Khan, T. Saxl, D.J.S. Birch

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Nanomedicine involves measurement and therapy at the level of 1-100 nm. Although the science is still in its infancy, it has major potential applications in diabetes. These include solving needs such as non-invasive glucose monitoring using implanted nanosensors, with key techniques being fluorescence resonance energy transfer (FRET) and fluorescence lifetime sensing, as well as new nano-encapsulation technologies for sensors such as layer-by-layer (LBL) films. The latter might also achieve better insulin delivery in diabetes by both improved islet encapsulation and oral insulin formulations. An artificial nanopancreas could be an alternative closed-loop insulin delivery system. Other applications of nanomedicine include targeted molecular imaging in vivo (e.g. tissue complications) using quantum dots (QDs) or gold nanoparticles, and single-molecule detection for the study of molecular diversity in diabetes pathology
Original languageEnglish
Pages (from-to)604-610
Number of pages6
JournalDiabetes-Metabolism Research and Reviews
Volume24
Issue number8
DOIs
Publication statusPublished - Nov 2008

Keywords

  • nanomedicine
  • glucose sensors
  • fluorescence
  • nanoparticles
  • insulin
  • single-molecule

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