Nano self-assemblies based on cholate grafted poly-L-lysine enhanced the solubility of sterol-like drugs

Jingxia Gu, Woei Ping Cheng, Clare Hoskins, Paul Kong Thoo Lin, Lingling Zhao, Lijun Zhu, Xiaozhong Qu, Zhenzong Yang

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The physicochemical compatibility between amphiphilic polymers and hydrophobic drugs has been recognized as an important issue for improving the drug solubilisation in polymeric micelle formulations. In this work, poly-L-lysine (PLL) grafted by cholate pendants as the only hydrophobic moiety were synthesized in order to facilitate the solubilisation of sterol drugs. Results showed that micelles formed by cholate grafted PLL encapsulated significantly higher level of prednisolone and estradiol than palmitoylated PLL micelles, whereas the solubilisation capacity of non-sterol drug (griseofulvin) is inefficient for both polymers. This suggests that higher drug-polymer incorporation can be achieved by the inclusion of hydrophobic moieties with similar architecture as the drugs, i.e. ‘drug-like’ functional groups, which will be useful for the future design of colloidal systems for the encapsulation of specific drug.
LanguageEnglish
Pages752-762
Number of pages11
JournalJournal of Microencapsulation
Volume28
Issue number8
DOIs
Publication statusPublished - 3 Nov 2011

Fingerprint

Cholates
lysine
Sterols
Micelles
Solubility
Self assembly
Lysine
self assembly
drugs
solubility
Polymers
Pharmaceutical Preparations
Encapsulation
micelles
Functional groups
polymers
Griseofulvin
Prednisolone
compatibility
Estradiol

Keywords

  • drug solubilisation
  • amphiphilic graft copolymer
  • micelle
  • drug-polymer interaction

Cite this

Gu, Jingxia ; Cheng, Woei Ping ; Hoskins, Clare ; Kong Thoo Lin, Paul ; Zhao, Lingling ; Zhu, Lijun ; Qu, Xiaozhong ; Yang, Zhenzong. / Nano self-assemblies based on cholate grafted poly-L-lysine enhanced the solubility of sterol-like drugs. In: Journal of Microencapsulation . 2011 ; Vol. 28, No. 8. pp. 752-762.
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Nano self-assemblies based on cholate grafted poly-L-lysine enhanced the solubility of sterol-like drugs. / Gu, Jingxia; Cheng, Woei Ping; Hoskins, Clare; Kong Thoo Lin, Paul; Zhao, Lingling; Zhu, Lijun; Qu, Xiaozhong; Yang, Zhenzong.

In: Journal of Microencapsulation , Vol. 28, No. 8, 03.11.2011, p. 752-762.

Research output: Contribution to journalArticle

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AU - Kong Thoo Lin, Paul

AU - Zhao, Lingling

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