Abstract
Venom from South African green mamba snakes (Dendroaspis angusticeps) produced a slow blockade of responses of chick isolated biventer cervicis preparations to indirect stimulation, acetylcholine, carbachol and, to a lesser extent, KCl. Responses of mouse diaphragm preparations to indirect stimulation increased and then decreased after addition of venom. Responses of toad rectus abdominis muscles to carbachol were reduced, while those to acetylcholine were augmented. Light and electron microscopy revealed that the venom caused extensive morphological damage to the chick and mouse preparations.
Original language | English |
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Pages (from-to) | 135-140 |
Number of pages | 6 |
Journal | Asia Pacific Journal of Pharmacology |
Volume | 7 |
Issue number | 2 |
Publication status | Published - 1 Jan 1992 |
Keywords
- acetylcholine
- carbachol
- potassium chloride
- snake venom
- animal tissue
- concentration response
- controlled study
- electron microscopy
- hemidiaphragm
- neuromuscular transmission
- green mamba
- dendroaspis angusticeps