Myotoxic effects in vitro of South African green mamba (Dendroaspis angusticeps) venom

A. L. Harvey, M. C.E. Gwee, L. S. Cheah, P. Gopalakrishnakone

Research output: Contribution to journalArticle

Abstract

Venom from South African green mamba snakes (Dendroaspis angusticeps) produced a slow blockade of responses of chick isolated biventer cervicis preparations to indirect stimulation, acetylcholine, carbachol and, to a lesser extent, KCl. Responses of mouse diaphragm preparations to indirect stimulation increased and then decreased after addition of venom. Responses of toad rectus abdominis muscles to carbachol were reduced, while those to acetylcholine were augmented. Light and electron microscopy revealed that the venom caused extensive morphological damage to the chick and mouse preparations.

Original languageEnglish
Pages (from-to)135-140
Number of pages6
JournalAsia Pacific Journal of Pharmacology
Volume7
Issue number2
Publication statusPublished - 1 Jan 1992

Keywords

  • acetylcholine
  • carbachol
  • potassium chloride
  • snake venom
  • animal tissue
  • concentration response
  • controlled study
  • electron microscopy
  • hemidiaphragm
  • neuromuscular transmission
  • green mamba
  • dendroaspis angusticeps

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