Mutations in succinate dehydrogenase B (SDHB) enhance neutrophil survival independent of HIF-1α expression

Robert Jones; Kate E. McDonald; Joseph A. Willson; Bart Ghesquière; David Sammut; Eleni Daniel; Alison J. Harris; Amy Lewis; A. A. Roger Thompson; Rebecca S. Dickinson; Tracie Plant; Fiona Murphy; Pranvera Sadiku; Brian G. Keevil; Peter Carmeliet; Moira K. B. Whyte; John Newell-Price; Sarah R. Walmsley

doi:10.1182/blood-2016-02-696922

Mutations in succinate dehydrogenase B (SDHB) enhance neutrophil survival independent of HIF-1α expression

Robert Jones, Kate E. McDonald, Joseph A. Willson, Bart Ghesquière, David Sammut, Eleni Daniel, Alison J. Harris, Amy Lewis, A. A. Roger Thompson, Rebecca S. Dickinson, Tracie Plant, Fiona Murphy, Pranvera Sadiku, Brian G. Keevil, Peter Carmeliet, Moira K. B. Whyte, John Newell-Price, Sarah R. Walmsley^*

^*Corresponding author for this work

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Letter › peer-review

26 Citations (Scopus)

Original language	English
Pages (from-to)	2641-2644
Number of pages	4
Journal	Blood
Volume	127
Issue number	21
DOIs	https://doi.org/10.1182/blood-2016-02-696922
Publication status	Published - 26 May 2016

Funding

This work was principally supported by Wellcome Trust Senior Clinical Fellowship Award 098516 (S.R.W.), Medical Research Council (MRC) Clinical Training Fellowship Awards G0802255 (A.A.R.T.) and MR/K023845/1 (R.S.D.), and an Engineering and Physical Sciences Research Council and MRC Centre for Doctoral Training in Optical Medical Imaging PhD studentship (J.A.W.). The MRC/University of Edinburgh Centre for Inflammation Research is supported by an MRC Centre grant. The study was also supported by Methusalem funding from the Flemish Government (P.C.).

Keywords

neutrophils
metabolic adaptation

Access to Document

10.1182/blood-2016-02-696922

Cite this

Jones, R., McDonald, K. E., Willson, J. A., Ghesquière, B., Sammut, D., Daniel, E., Harris, A. J., Lewis, A., Thompson, A. A. R., Dickinson, R. S., Plant, T., Murphy, F., Sadiku, P., Keevil, B. G., Carmeliet, P., Whyte, M. K. B., Newell-Price, J., & Walmsley, S. R. (2016). Mutations in succinate dehydrogenase B (SDHB) enhance neutrophil survival independent of HIF-1α expression. Blood, 127(21), 2641-2644. https://doi.org/10.1182/blood-2016-02-696922

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keywords = "neutrophils, metabolic adaptation",

author = "Robert Jones and McDonald, \{Kate E.\} and Willson, \{Joseph A.\} and Bart Ghesqui{\`e}re and David Sammut and Eleni Daniel and Harris, \{Alison J.\} and Amy Lewis and Thompson, \{A. A. Roger\} and Dickinson, \{Rebecca S.\} and Tracie Plant and Fiona Murphy and Pranvera Sadiku and Keevil, \{Brian G.\} and Peter Carmeliet and Whyte, \{Moira K. B.\} and John Newell-Price and Walmsley, \{Sarah R.\}",

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doi = "10.1182/blood-2016-02-696922",

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Jones, R, McDonald, KE, Willson, JA, Ghesquière, B, Sammut, D, Daniel, E, Harris, AJ, Lewis, A, Thompson, AAR, Dickinson, RS, Plant, T, Murphy, F, Sadiku, P, Keevil, BG, Carmeliet, P, Whyte, MKB, Newell-Price, J & Walmsley, SR 2016, 'Mutations in succinate dehydrogenase B (SDHB) enhance neutrophil survival independent of HIF-1α expression', Blood, vol. 127, no. 21, pp. 2641-2644. https://doi.org/10.1182/blood-2016-02-696922

TY - JOUR

T1 - Mutations in succinate dehydrogenase B (SDHB) enhance neutrophil survival independent of HIF-1α expression

AU - Jones, Robert

AU - McDonald, Kate E.

AU - Willson, Joseph A.

AU - Ghesquière, Bart

AU - Sammut, David

AU - Daniel, Eleni

AU - Harris, Alison J.

AU - Lewis, Amy

AU - Thompson, A. A. Roger

AU - Dickinson, Rebecca S.

AU - Plant, Tracie

AU - Murphy, Fiona

AU - Sadiku, Pranvera

AU - Keevil, Brian G.

AU - Carmeliet, Peter

AU - Whyte, Moira K. B.

AU - Newell-Price, John

AU - Walmsley, Sarah R.

PY - 2016/5/26

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KW - neutrophils

KW - metabolic adaptation

U2 - 10.1182/blood-2016-02-696922

DO - 10.1182/blood-2016-02-696922

M3 - Letter

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AN - SCOPUS:84993995673

SN - 0006-4971

VL - 127

SP - 2641

EP - 2644

JO - Blood

JF - Blood

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ER -