Mussel-inspired silver-releasing antibacterial hydrogels

D. E. Fullenkamp, J. G. Rivera, Y. K. Gong, K. H. A. Lau, L. H. He, R. Varshney, P. B. Messersmith

Research output: Contribution to journalArticle

138 Citations (Scopus)

Abstract

A silver-releasing antibacterial hydrogel was developed that simultaneously allowed for silver nanoparticle formation and gel curing. Water-soluble polyethylene glycol (PEG) polymers were synthesized that contain reactive catechol moieties, inspired by mussel adhesive proteins, where the catechol containing amino acid 3,4-dihydroxyphenylalanine (DOPA) plays an important role in the ability of the mussel to adhere to almost any surface in an aqueous environment. We utilized silver nitrate to oxidize polymer catechols, leading to covalent cross-linking and hydrogel formation with simultaneous reduction of Ag(I). Silver release was sustained for periods of at least two weeks in PBS solution. Hydrogels were found to inhibit bacterial growth, consistent with the well-known antibacterial properties of silver, while not significantly affecting mammalian cell viability. In addition, thin hydrogel films were found to resist bacterial and mammalian cell attachment, consistent with the antifouling properties of PEG. We believe these materials have a strong potential for antibacterial biomaterial coatings and tissue adhesives, due to the material-independent adhesive properties of catechols. (C) 2012 Elsevier Ltd. All rights reserved.
LanguageEnglish
Pages3783-3791
Number of pages9
JournalBiomaterials
Volume33
Issue number15
DOIs
Publication statusPublished - May 2012

Fingerprint

Hydrogels
Bivalvia
Silver
Catechols
Hydrogel
Adhesives
Polymers
Cells
Polyethylene glycols
Tissue Adhesives
Silver Nitrate
Dihydroxyphenylalanine
Biocompatible Materials
Nanoparticles
Curing
Cell Survival
Biomaterials
Gels
Amino acids
Nitrates

Keywords

  • dopa
  • oxide
  • silver
  • hydrogel
  • antibacterial
  • biomimetic material
  • nanoparticle adhesive proteins
  • medicine
  • biology
  • mimics
  • burns

Cite this

Fullenkamp, D. E., Rivera, J. G., Gong, Y. K., Lau, K. H. A., He, L. H., Varshney, R., & Messersmith, P. B. (2012). Mussel-inspired silver-releasing antibacterial hydrogels. Biomaterials, 33(15), 3783-3791. https://doi.org/10.1016/j.biomaterials.2012.02.027
Fullenkamp, D. E. ; Rivera, J. G. ; Gong, Y. K. ; Lau, K. H. A. ; He, L. H. ; Varshney, R. ; Messersmith, P. B. / Mussel-inspired silver-releasing antibacterial hydrogels. In: Biomaterials. 2012 ; Vol. 33, No. 15. pp. 3783-3791.
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Fullenkamp, DE, Rivera, JG, Gong, YK, Lau, KHA, He, LH, Varshney, R & Messersmith, PB 2012, 'Mussel-inspired silver-releasing antibacterial hydrogels' Biomaterials, vol. 33, no. 15, pp. 3783-3791. https://doi.org/10.1016/j.biomaterials.2012.02.027

Mussel-inspired silver-releasing antibacterial hydrogels. / Fullenkamp, D. E.; Rivera, J. G.; Gong, Y. K.; Lau, K. H. A.; He, L. H.; Varshney, R.; Messersmith, P. B.

In: Biomaterials, Vol. 33, No. 15, 05.2012, p. 3783-3791.

Research output: Contribution to journalArticle

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Fullenkamp DE, Rivera JG, Gong YK, Lau KHA, He LH, Varshney R et al. Mussel-inspired silver-releasing antibacterial hydrogels. Biomaterials. 2012 May;33(15):3783-3791. https://doi.org/10.1016/j.biomaterials.2012.02.027