Multivalent nanoparticle networks as ultrasensitive enzyme sensors

Roberto De La Rica, Raluca Fratila, Anna Szarpak, Jurriaan Huskens, Aldrik Velders

Research output: Contribution to journalArticlepeer-review

63 Citations (Scopus)


As few as 23 enzyme molecules could be detected on the basis of the dispersion of Au nanoparticles in a model bioassay whose sensitivity was boosted by the interplay between multivalent and monovalent supramolecular interactions: a diferrocenyl ligand (red) caused the assembly of nanoparticle clusters; upon its oxidation, a competing monovalent guest molecule (blue) favored the formation of monovalent interactions for more efficient
Original languageEnglish
Pages (from-to)5704–5707
Number of pages4
JournalAngewandte Chemie International Edition
Issue number25
Early online date17 May 2011
Publication statusPublished - 14 Jun 2011


  • biosensors
  • cyclodextrins
  • enzymes
  • gold
  • supramolecular chemistry


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