Multivalent nanoparticle networks as ultrasensitive enzyme sensors

Roberto De La Rica; Raluca Fratila; Anna Szarpak; Jurriaan Huskens; Aldrik Velders

doi:10.1002/anie.201008189

Multivalent nanoparticle networks as ultrasensitive enzyme sensors

Roberto De La Rica, Raluca Fratila, Anna Szarpak, Jurriaan Huskens, Aldrik Velders

Physics

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Abstract

As few as 23 enzyme molecules could be detected on the basis of the dispersion of Au nanoparticles in a model bioassay whose sensitivity was boosted by the interplay between multivalent and monovalent supramolecular interactions: a diferrocenyl ligand (red) caused the assembly of nanoparticle clusters; upon its oxidation, a competing monovalent guest molecule (blue) favored the formation of monovalent interactions for more efficient

Original language	English
Pages (from-to)	5704–5707
Number of pages	4
Journal	Angewandte Chemie International Edition
Volume	50
Issue number	25
Early online date	17 May 2011
DOIs	https://doi.org/10.1002/anie.201008189
Publication status	Published - 14 Jun 2011

Keywords

biosensors
cyclodextrins
enzymes
gold
supramolecular chemistry

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AU - De La Rica, Roberto

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AU - Szarpak, Anna

AU - Huskens, Jurriaan

AU - Velders, Aldrik

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KW - biosensors

KW - cyclodextrins

KW - enzymes

KW - gold

KW - supramolecular chemistry

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M3 - Article

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JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

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Multivalent nanoparticle networks as ultrasensitive enzyme sensors

Abstract

Keywords

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