Projects per year
Abstract
The standard drug discovery paradigm of single molecule - single biological target - single biological effect is perhaps particularly unsuitable for anti-infective drug discovery. This is due to the rapid evolution of resistance likely to be observed with single target drugs. Multi-targeted anti-infective drugs (MTAIDs) are likely to be superior due to their lower susceptibility to target-related resistance mechanisms. Strathclyde Minor Groove Binders (S-MGBs) are a class of compounds which have been developed by adopting the MTAID paradigm, and their effectiveness against a wide range of pathogenic organisms is discussed. The renaming of this class to Strathclyde Nucleic Acid Binders (SNABs) is also presented due to their likely targets including both DNA and RNA.
Original language | English |
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Number of pages | 14 |
Journal | Future Drug Discovery |
Volume | 4 |
Issue number | 1 |
Early online date | 5 May 2022 |
DOIs | |
Publication status | Published - 5 May 2022 |
Keywords
- anti-infectives
- multi-targeting anti-infective drugs
- antimicrobial resistance
- Strathclyde Minor Groove Binders (S-MGBs)
- Strathclyde Nucleic Acid Binders (SNABs)
- nucleic acids
- RNA
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Dive into the research topics of 'Multitargeted anti-infective drugs: resilience to resistance in the antimicrobial resistance era'. Together they form a unique fingerprint.Projects
- 4 Finished
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Investigating a novel class of Gram-negative active antibiotic suitable for clinical use
Scott, F. (Principal Investigator), Hunter, I. (Co-investigator), Suckling, C. (Co-investigator) & Tucker, N. (Co-investigator)
1/11/20 → 30/04/23
Project: Research
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Tackling MDR Gram-negative infections by an MGB conjugation strategy. WT Grant Transfer
Scott, F. (Principal Investigator)
1/09/19 → 31/12/19
Project: Research
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A new drug discovery pipeline for animal African trypanosomiasis
Suckling, C. (Principal Investigator) & Burley, G. (Co-investigator)
Global Alliance for Livestock Veterinary Medicines (GALVmed), BBSRC (Biotech & Biological Sciences Research Council)
1/04/16 → 31/03/20
Project: Research