Multistage, multi-zones antisolvent-cooling crystallisation of a proprietary API: experimental comparison of effect of geometry and hydrodynamics in four batch crystallisers

Ebenezer Ojo, Musab Osman, Mitchelle Mnemo, Ali Anwar, Ian Houson, Ruairi O'Meahdra, Schenkel Berthold, Alastair Florence

Research output: Contribution to conferencePoster

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Abstract

Early decision making of batch vs continuous and which type of crystalliser to select is a key decision point. Four different lab-scale (100’s ml) crystallisers were investigated and compared for multistage, multi--zone, antisolvent-cooling crystallisation of a proprietary anticancer active pharmaceutical ingredient (API). The seeding load (1&5%), antisolvent addition rate and residence times were fixed across all four platforms based on fixed process conditions. This work aims to enable decision making earlier in the development cycle by understanding how batch reactors compare to their continuous counterparts. Investigate how to run small scale "batch" experiments to replicate continuous performance. Develop a comparative basis to select an ideal crystalliser for early stage development with less material than is currently possible.
Original languageEnglish
Number of pages1
Publication statusPublished - 21 Oct 2020
EventCMAC Annual Open Day - Virtual event, Glasgow, United Kingdom
Duration: 21 Oct 202022 Oct 2020

Conference

ConferenceCMAC Annual Open Day
Country/TerritoryUnited Kingdom
CityGlasgow
Period21/10/2022/10/20

Keywords

  • hydrodynamics
  • crystalization
  • batch crystalising
  • continuous crystallisation

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