Multisite microLED optrode array for neural interfacing

Niall McAlinden, Yunzhou Cheng, Robert Scharf, Enyuan Xie, Erdan Gu, Christopher F. Reiche, Rohit Sharma, Prashant Tathireddy, Martin D. Dawson, Loren Rieth, Steve Blair, Keith Mathieson

Research output: Contribution to journalArticle

Abstract

We present an electrically addressable optrode array capable of delivering light to 181 sites in the brain, each providing sufficient light to optogenetically excite thousands of neurons in vivo, developed with the aim to allow behavioral studies in large mammals. The device is a glass microneedle array directly integrated with a custom fabricated microLED device, which delivers light to 100 needle tips and 81 interstitial surface sites, giving two-level optogenetic excitation of neurons in vivo. Light delivery and thermal properties are evaluated, with the device capable of peak irradiances >80  mW  /  mm2 per needle site. The device consists of an array of 181 80  μm  ×  80  μm2 microLEDs, fabricated on a 150-μm-thick GaN-on-sapphire wafer, coupled to a glass needle array on a 150-μm thick backplane. A pinhole layer is patterned on the sapphire side of the microLED array to reduce stray light. Future designs are explored through optical and thermal modeling and benchmarked against the current device.
LanguageEnglish
Article number035010
Number of pages9
JournalNeurophotonics
Volume6
Issue number3
DOIs
Publication statusPublished - 28 Aug 2019

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needles
neurons
sapphire
mammals
glass
pinholes
irradiance
brain
delivery
interstitials
thermodynamic properties
wafers
excitation

Keywords

  • optogenetics
  • neurotechnology
  • waveguide
  • optical modeling
  • microLED

Cite this

McAlinden, Niall ; Cheng, Yunzhou ; Scharf, Robert ; Xie, Enyuan ; Gu, Erdan ; Reiche, Christopher F. ; Sharma, Rohit ; Tathireddy, Prashant ; Dawson, Martin D. ; Rieth, Loren ; Blair, Steve ; Mathieson, Keith. / Multisite microLED optrode array for neural interfacing. 2019 ; Vol. 6, No. 3.
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Multisite microLED optrode array for neural interfacing. / McAlinden, Niall; Cheng, Yunzhou; Scharf, Robert; Xie, Enyuan; Gu, Erdan; Reiche, Christopher F.; Sharma, Rohit; Tathireddy, Prashant; Dawson, Martin D.; Rieth, Loren; Blair, Steve; Mathieson, Keith.

Vol. 6, No. 3, 035010, 28.08.2019.

Research output: Contribution to journalArticle

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AU - Cheng, Yunzhou

AU - Scharf, Robert

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AU - Reiche, Christopher F.

AU - Sharma, Rohit

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AU - Blair, Steve

AU - Mathieson, Keith

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