Multiplexed profiling of extracellular vesicles for biomarker development

Cheng Jiang, Ying Fu, Guozhen Liu, Bowen Shu, Jason Davis, George K. Tofaris

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)
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Extracellular vesicles (EVs) are cell-derived membranous particles that play a crucial role in molecular trafficking, intercellular transport and the egress of unwanted proteins. They have been implicated in many diseases including cancer and neurodegeneration. EVs are detected in all bodily fluids, and their protein and nucleic acid content offers a means of assessing the status of the cells from which they originated. As such, they provide opportunities in biomarker discovery for diagnosis, prognosis or the stratification of diseases as well as an objective monitoring of therapies. The simultaneous assaying of multiple EV-derived markers will be required for an impactful practical application, and multiplexing platforms have evolved with the potential to achieve this. Herein, we provide a comprehensive overview of the currently available multiplexing platforms for EV analysis, with a primary focus on miniaturized and integrated devices that offer potential step changes in analytical power, throughput and consistency.
Original languageEnglish
Number of pages36
JournalNano-Micro Letters
Early online date2 Dec 2021
Publication statusPublished - 2 Dec 2021


  • multiplexed profile
  • extracellular vesicles
  • exosomes
  • liquid biopsy
  • point-of-care
  • biomarker


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