Multiplex in vitro detection using SERS

Stacey Laing, Kirsten Gracie, Karen Faulds

Research output: Contribution to journalArticlepeer-review

179 Citations (Scopus)
307 Downloads (Pure)


The ability to detect multiple disease-related targets from a single biological sample in a quick and reliable manner is of high importance in diagnosing and monitoring disease. The technique known as surface enhanced Raman scattering (SERS) has been developed for the simultaneous detection of multiple targets present in biological samples. Advances in the SERS method have allowed for the sensitive and specific detection of biologically relevant targets, such as DNA and proteins, which could be useful for the detection and control of disease. This review focuses on the strengths of SERS for the detection of target molecules from complex mixtures and the clinical relevance of recent work combining SERS with multiplexed detection of biological targets.
Original languageEnglish
Pages (from-to)1901-1918
Number of pages18
JournalChemical Society Reviews
Issue number7
Early online date21 Dec 2015
Publication statusPublished - 7 Apr 2016


  • SERS
  • assays
  • detection of disease
  • control of disease
  • multiple targets

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