Multiplex in vitro detection using SERS

Stacey Laing, Kirsten Gracie, Karen Faulds

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

The ability to detect multiple disease-related targets from a single biological sample in a quick and reliable manner is of high importance in diagnosing and monitoring disease. The technique known as surface enhanced Raman scattering (SERS) has been developed for the simultaneous detection of multiple targets present in biological samples. Advances in the SERS method have allowed for the sensitive and specific detection of biologically relevant targets, such as DNA and proteins, which could be useful for the detection and control of disease. This review focuses on the strengths of SERS for the detection of target molecules from complex mixtures and the clinical relevance of recent work combining SERS with multiplexed detection of biological targets.
LanguageEnglish
Pages1901-1918
Number of pages18
JournalChemical Society Reviews
Volume45
Issue number7
Early online date21 Dec 2015
DOIs
Publication statusPublished - 7 Apr 2016

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Raman Spectrum Analysis
Raman scattering
Complex Mixtures
Molecules
In Vitro Techniques
Monitoring
DNA
Proteins

Keywords

  • SERS
  • assays
  • detection of disease
  • control of disease
  • multiple targets

Cite this

Laing, Stacey ; Gracie, Kirsten ; Faulds, Karen. / Multiplex in vitro detection using SERS. In: Chemical Society Reviews. 2016 ; Vol. 45, No. 7. pp. 1901-1918.
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Multiplex in vitro detection using SERS. / Laing, Stacey; Gracie, Kirsten; Faulds, Karen.

In: Chemical Society Reviews, Vol. 45, No. 7, 07.04.2016, p. 1901-1918.

Research output: Contribution to journalArticle

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