Multi-nuclear platinum complexes encapsulated in cucurbit[n]uril as an approach to reduce toxicity in cancer treatment

N.J. Wheate, A.I. Day, R.J. Blanch, A.P. Arnold, C. Cullinane, J.G. Collins

Research output: Contribution to journalArticle

139 Citations (Scopus)

Abstract

The dinuclear platinum complex trans-[{Pt(NH3)2Cl}2μ-dpzm]2+ (di-Pt) binds inside cucurbit[7]uril with slow exchange kinetics which does not significantly affect the cytotoxicity of the dinuclear complex but reactivity at the platinum centre is reduced.
Original languageEnglish
Pages (from-to)1424-1425
Number of pages2
JournalChemical Communications (London)
Volume12
DOIs
Publication statusPublished - 2004

Keywords

  • toxicity
  • cancer treatment
  • platinum complexes

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