Multi-nuclear platinum complexes encapsulated in cucurbit[n]uril as an approach to reduce toxicity in cancer treatment

N.J. Wheate; A.I. Day; R.J. Blanch; A.P. Arnold; C. Cullinane; J.G. Collins

doi:10.1039/b404358h

Multi-nuclear platinum complexes encapsulated in cucurbit[n]uril as an approach to reduce toxicity in cancer treatment

N.J. Wheate, A.I. Day, R.J. Blanch, A.P. Arnold, C. Cullinane, J.G. Collins

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

152 Citations (Scopus)

Abstract

The dinuclear platinum complex trans-[{Pt(NH3)2Cl}2μ-dpzm]2+ (di-Pt) binds inside cucurbit[7]uril with slow exchange kinetics which does not significantly affect the cytotoxicity of the dinuclear complex but reactivity at the platinum centre is reduced.

Original language	English
Pages (from-to)	1424-1425
Number of pages	2
Journal	Chemical Communications (London)
Volume	12
DOIs	https://doi.org/10.1039/b404358h
Publication status	Published - 2004

Keywords

toxicity
cancer treatment
platinum complexes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/b404358h

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title = "Multi-nuclear platinum complexes encapsulated in cucurbit[n]uril as an approach to reduce toxicity in cancer treatment",

abstract = "The dinuclear platinum complex trans-[{Pt(NH3)2Cl}2μ-dpzm]2+ (di-Pt) binds inside cucurbit[7]uril with slow exchange kinetics which does not significantly affect the cytotoxicity of the dinuclear complex but reactivity at the platinum centre is reduced.",

keywords = "toxicity , cancer treatment, platinum complexes ",

author = "N.J. Wheate and A.I. Day and R.J. Blanch and A.P. Arnold and C. Cullinane and J.G. Collins",

year = "2004",

doi = "10.1039/b404358h",

language = "English",

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journal = "Chemical Communications (London)",

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T1 - Multi-nuclear platinum complexes encapsulated in cucurbit[n]uril as an approach to reduce toxicity in cancer treatment

AU - Wheate, N.J.

AU - Day, A.I.

AU - Blanch, R.J.

AU - Arnold, A.P.

AU - Cullinane, C.

AU - Collins, J.G.

PY - 2004

Y1 - 2004

N2 - The dinuclear platinum complex trans-[{Pt(NH3)2Cl}2μ-dpzm]2+ (di-Pt) binds inside cucurbit[7]uril with slow exchange kinetics which does not significantly affect the cytotoxicity of the dinuclear complex but reactivity at the platinum centre is reduced.

AB - The dinuclear platinum complex trans-[{Pt(NH3)2Cl}2μ-dpzm]2+ (di-Pt) binds inside cucurbit[7]uril with slow exchange kinetics which does not significantly affect the cytotoxicity of the dinuclear complex but reactivity at the platinum centre is reduced.

KW - toxicity

KW - cancer treatment

KW - platinum complexes

U2 - 10.1039/b404358h

DO - 10.1039/b404358h

M3 - Article

VL - 12

SP - 1424

EP - 1425

JO - Chemical Communications (London)

JF - Chemical Communications (London)

SN - 0009-241X

ER -

Multi-nuclear platinum complexes encapsulated in cucurbit[n]uril as an approach to reduce toxicity in cancer treatment

Abstract

Keywords

UN SDGs

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