mTORC1 phosphorylates the ULK1-mAtg13-FIP200 autophagy regulatory complex

Edmond Y Chan

Research output: Contribution to journalLiterature review

136 Citations (Scopus)

Abstract

High nutrient availability stimulates the mammalian target of rapamycin complex 1 (mTORC1) to coordinately activate anabolic processes, such as protein synthesis, while inhibiting the cellular catabolism of autophagy. Positive regulation of protein synthesis through the mTORC1 substrates p70 ribosomal S6 kinase (p70S6K) and eukaryotic initiation factor 4E binding protein 1 (4E-BP1) has been well characterized. The complementary inhibitory mechanism in which mTORC1 phosphorylates the autophagy regulatory complex containing unc-51-like kinase 1 (ULK1), the mammalian Atg13 protein, and focal adhesion kinase interacting protein of 200 kD (FIP200) has also been elucidated.
LanguageEnglish
Pagespe51
JournalScience Signaling
Volume2
Issue number84
DOIs
Publication statusPublished - 18 Aug 2009

Fingerprint

Autophagy
Phosphotransferases
Proteins
Eukaryotic Initiation Factor-4E
Ribosomal Protein S6 Kinases
70-kDa Ribosomal Protein S6 Kinases
Focal Adhesion Protein-Tyrosine Kinases
Nutrients
Carrier Proteins
Availability
Food
Autophagy-Related Protein-1 Homolog
mechanistic target of rapamycin complex 1
Substrates

Keywords

  • adaptor proteins
  • animals
  • autophagy
  • humans
  • intracellular signaling peptides
  • biological models
  • phosphorylation
  • protein-serine-threonine kinases
  • protein-tyrosine kinases
  • signal transduction
  • transcription factors

Cite this

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title = "mTORC1 phosphorylates the ULK1-mAtg13-FIP200 autophagy regulatory complex",
abstract = "High nutrient availability stimulates the mammalian target of rapamycin complex 1 (mTORC1) to coordinately activate anabolic processes, such as protein synthesis, while inhibiting the cellular catabolism of autophagy. Positive regulation of protein synthesis through the mTORC1 substrates p70 ribosomal S6 kinase (p70S6K) and eukaryotic initiation factor 4E binding protein 1 (4E-BP1) has been well characterized. The complementary inhibitory mechanism in which mTORC1 phosphorylates the autophagy regulatory complex containing unc-51-like kinase 1 (ULK1), the mammalian Atg13 protein, and focal adhesion kinase interacting protein of 200 kD (FIP200) has also been elucidated.",
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mTORC1 phosphorylates the ULK1-mAtg13-FIP200 autophagy regulatory complex. / Chan, Edmond Y.

In: Science Signaling, Vol. 2, No. 84, 18.08.2009, p. pe51.

Research output: Contribution to journalLiterature review

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N2 - High nutrient availability stimulates the mammalian target of rapamycin complex 1 (mTORC1) to coordinately activate anabolic processes, such as protein synthesis, while inhibiting the cellular catabolism of autophagy. Positive regulation of protein synthesis through the mTORC1 substrates p70 ribosomal S6 kinase (p70S6K) and eukaryotic initiation factor 4E binding protein 1 (4E-BP1) has been well characterized. The complementary inhibitory mechanism in which mTORC1 phosphorylates the autophagy regulatory complex containing unc-51-like kinase 1 (ULK1), the mammalian Atg13 protein, and focal adhesion kinase interacting protein of 200 kD (FIP200) has also been elucidated.

AB - High nutrient availability stimulates the mammalian target of rapamycin complex 1 (mTORC1) to coordinately activate anabolic processes, such as protein synthesis, while inhibiting the cellular catabolism of autophagy. Positive regulation of protein synthesis through the mTORC1 substrates p70 ribosomal S6 kinase (p70S6K) and eukaryotic initiation factor 4E binding protein 1 (4E-BP1) has been well characterized. The complementary inhibitory mechanism in which mTORC1 phosphorylates the autophagy regulatory complex containing unc-51-like kinase 1 (ULK1), the mammalian Atg13 protein, and focal adhesion kinase interacting protein of 200 kD (FIP200) has also been elucidated.

KW - adaptor proteins

KW - animals

KW - autophagy

KW - humans

KW - intracellular signaling peptides

KW - biological models

KW - phosphorylation

KW - protein-serine-threonine kinases

KW - protein-tyrosine kinases

KW - signal transduction

KW - transcription factors

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DO - 10.1126/scisignal.284pe51

M3 - Literature review

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SP - pe51

JO - Science Signaling

T2 - Science Signaling

JF - Science Signaling

SN - 1945-0877

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